| Can Roux-en-Y gastric bypass provide a lifelong solution for diabetes mellitus? | |
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MedLine Citation:
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PMID: 20011163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The surgical treatment of diabetes had witnessed progressive development and success since the first case of pancreatic transplantation. Although this was a great step, wide clinical application was limited by several factors. Bariatric surgery such as gastric bypass is emerging as a promising option in obese patients with type 2 diabetes. The aim of this article is to explore the current application of gastric bypass in patients with type 2 diabetes and the theoretical bases of gastric bypass as a treatment option for type 1 diabetes. METHODS: We performed a MEDLINE search for articles published from August 1955 to December 2008 using the words "surgical treatment of diabetes," "etiology of diabetes" and "gastric bypass." RESULTS: We identified 3215 studies and selected 72 relevant papers for review. Surgical treatment of diabetes is evolving from complex pancreatic and islets transplantation surgery for type 1 diabetes with critical postoperative outcome and follow-up to a metabolic surgery, including gastric bypass. Gastric bypass (no immune suppression or graft rejection) has proven to be highly effective treatment for obese patients and nonobese animals with type 2 diabetes. There are certain shared criteria between types 1 and 2 diabetes, making a selected spectrum of the disease a potential target for metabolic surgery to improve or cure diabetes. CONCLUSION: Roux-en-Y gastric bypass is a promising option for lifelong treatment of type 2 diabetes. It has the potential to improve or cure a selected spectrum of type 1 diabetes when performed early in the disease. Further animal model studies or randomized controlled trials are needed to support our conclusion. |
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Authors:
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Abdulzahra Hussain; Hind Mahmood; Shamsi El-Hasani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of surgery. Journal canadien de chirurgie Volume: 52 ISSN: 1488-2310 ISO Abbreviation: Can J Surg Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2009-12-28 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0372715 Medline TA: Can J Surg Country: Canada |
Other Details:
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Languages: eng Pagination: E269-75 Citation Subset: IM |
Affiliation:
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Minimal Access and Bariatric Surgery Unit, General Surgery Department, Princess Royal University Hospital, Orpington, Greater London, UK. azahrahussain@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 1
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complications,
surgery* Diabetes Mellitus, Type 2 / complications, surgery* Gastric Bypass* Humans Obesity, Morbid / complications, surgery* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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