Document Detail

Can the National Health and Nutrition Examination Survey III (NHANES III) data help resolve the controversy over low blood lead levels and neuropsychological development in children?
MedLine Citation:
PMID:  14591457     Owner:  NLM     Status:  MEDLINE    
The National Health and Nutrition Examination Survey III (NHANES III) was designed to provide national estimates of the health and nutritional status of the United States population aged 2 months and above. A Youth data subset includes individuals from ages 2 months to 16 years totaling 13,944 individuals. Lanphear, Dietrich, Auinger, and Cox [U.S. Department of Health and Human Services, Public Health Reports, Public Health Report 2000, Vol. 115, p. 521] examined these data and concluded that deficits in cognitive and academic skills associated with lead exposure occur at blood lead concentrations of less than 5microg/dl. Attempts to replicate and extend these findings reveal serious shortcomings in the NHANES III data that center around missing data, odd distributions of blood lead levels as well as cognitive and academic scores, and potential inaccuracies in the data collection itself. A review of these issues is presented along with a series of empirical analyses of the data under multiple sets of assumptions leading to the conclusion that the NHANES III data are inherently inadequate for use in addressing neurodevelopmental issues. Policy issues and scientific issues related to cognitive and other neurodevelopmental phenomena should not be considered on the basis of the NHANES III Youth dataset.
Brice M Stone; Cecil R Reynolds
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists     Volume:  18     ISSN:  0887-6177     ISO Abbreviation:  Arch Clin Neuropsychol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-10-31     Completed Date:  2003-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9004255     Medline TA:  Arch Clin Neuropsychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-44     Citation Subset:  IM    
Brice Stone Consulting and Metrica, Inc., San Antonio, TX 78217-6363, USA.
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MeSH Terms
Child Development*
Child, Preschool
Cognition Disorders / chemically induced,  epidemiology*
Educational Status*
Environmental Pollutants / blood*,  toxicity
Health Status
Health Surveys*
Lead / blood*,  toxicity
Longitudinal Studies
Psychomotor Performance
United States / epidemiology
Reg. No./Substance:
0/Environmental Pollutants; 7439-92-1/Lead
Erratum In:
Arch Clin Neuropsychol. 2004 Aug;19(5):711-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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