Document Detail

Can mean central corneal thickness and its 24-hour fluctuation influence fluctuation of intraocular pressure?
MedLine Citation:
PMID:  19661818     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the influence of central corneal thickness (CCT) and its 24-hour fluctuation on 24-hour intraocular pressure (IOP) fluctuation in primary open-angle glaucoma. METHODS: Forty consecutive patients underwent 24-hour evaluation (8 PM, midnight, 4 AM, 8 AM, noon, and 4 PM) of supine and sitting IOP, measured with handheld Perkins and Goldmann tonometer respectively, and of CCT measured using ultrasonic pachymeter. Thirty patients were treated with timolol 0.5% twice daily and latanoprost 0.005% once daily; 10 patients were untreated. Measurements were taken in both eyes, but only one eye per patient was used for analytical purposes. Three IOP curves were drawn: sitting position, supine position, and habitual body position (diurnal sitting measurements and nocturnal supine measurements). Fluctuation was calculated as the SD over the 24-hour curve. Differences in the 2 groups were inspected by means of t test; the correlations between IOP fluctuation and mean CCT, respectively, and its fluctuation were evaluated by means of regression analysis. RESULTS: Untreated patients had higher IOP than the treated group (habitual body position: 22.1+/-5.1 mm Hg vs. 16.0+/-3.0 mm Hg, P=0.004), but no differences were found for IOP fluctuations (habitual body position: 2.5+/-1.2 mm Hg vs. 2.3+/-0.8 mm Hg, P=0.32), mean CCT (542+/-38 microm vs. 534+/-39 microm, P=0.44), and CCT fluctuation (8.7+/-5.6 microm vs. 6.5+/-3.0 microm, P=0.09). The correlation between IOP fluctuation and mean CCT and its fluctuation was not statistically significant at supine, sitting and habitual body positions (P>or=0.07; R<or=0.20). CONCLUSIONS: Twenty-four-hour IOP fluctuation was independent from CCT parameters in both treated and untreated glaucoma patients, regardless of body position at which IOP was measured.
Paolo Fogagnolo; Federica Capizzi; Nicola Orzalesi; Michele Figus; Antonio Ferreras; Luca Rossetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  19     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-23     Citation Subset:  IM    
G.B. Bietti Foudation-IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy.
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MeSH Terms
Aged, 80 and over
Antihypertensive Agents / therapeutic use
Circadian Rhythm / physiology*
Cornea / physiopathology*
Glaucoma, Open-Angle / drug therapy,  physiopathology*
Intraocular Pressure / physiology*
Middle Aged
Tonometry, Ocular
Reg. No./Substance:
0/Antihypertensive Agents

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