| Can mean central corneal thickness and its 24-hour fluctuation influence fluctuation of intraocular pressure? | |
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MedLine Citation:
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PMID: 19661818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the influence of central corneal thickness (CCT) and its 24-hour fluctuation on 24-hour intraocular pressure (IOP) fluctuation in primary open-angle glaucoma. METHODS: Forty consecutive patients underwent 24-hour evaluation (8 PM, midnight, 4 AM, 8 AM, noon, and 4 PM) of supine and sitting IOP, measured with handheld Perkins and Goldmann tonometer respectively, and of CCT measured using ultrasonic pachymeter. Thirty patients were treated with timolol 0.5% twice daily and latanoprost 0.005% once daily; 10 patients were untreated. Measurements were taken in both eyes, but only one eye per patient was used for analytical purposes. Three IOP curves were drawn: sitting position, supine position, and habitual body position (diurnal sitting measurements and nocturnal supine measurements). Fluctuation was calculated as the SD over the 24-hour curve. Differences in the 2 groups were inspected by means of t test; the correlations between IOP fluctuation and mean CCT, respectively, and its fluctuation were evaluated by means of regression analysis. RESULTS: Untreated patients had higher IOP than the treated group (habitual body position: 22.1+/-5.1 mm Hg vs. 16.0+/-3.0 mm Hg, P=0.004), but no differences were found for IOP fluctuations (habitual body position: 2.5+/-1.2 mm Hg vs. 2.3+/-0.8 mm Hg, P=0.32), mean CCT (542+/-38 microm vs. 534+/-39 microm, P=0.44), and CCT fluctuation (8.7+/-5.6 microm vs. 6.5+/-3.0 microm, P=0.09). The correlation between IOP fluctuation and mean CCT and its fluctuation was not statistically significant at supine, sitting and habitual body positions (P>or=0.07; R<or=0.20). CONCLUSIONS: Twenty-four-hour IOP fluctuation was independent from CCT parameters in both treated and untreated glaucoma patients, regardless of body position at which IOP was measured. |
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Authors:
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Paolo Fogagnolo; Federica Capizzi; Nicola Orzalesi; Michele Figus; Antonio Ferreras; Luca Rossetti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of glaucoma Volume: 19 ISSN: 1536-481X ISO Abbreviation: J. Glaucoma Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9300903 Medline TA: J Glaucoma Country: United States |
Other Details:
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Languages: eng Pagination: 418-23 Citation Subset: IM |
Affiliation:
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G.B. Bietti Foudation-IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy. fogagnolopaolo@googlemail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antihypertensive Agents / therapeutic use Circadian Rhythm / physiology* Cornea / physiopathology* Female Glaucoma, Open-Angle / drug therapy, physiopathology* Humans Intraocular Pressure / physiology* Male Middle Aged Posture Tonometry, Ocular |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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