| Can EGCG reduce abdominal fat in obese subjects? | |
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MedLine Citation:
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PMID: 17906193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate metabolic effects of epigallocatechin gallate (EGCG) supplementation when combined with a program of regular aerobic exercise in overweight/obese post-menopausal women. METHODS: Thirty-eight overweight or obese postmenopausal women exercised at moderate intensity, viz. walking three times per week for 45 min at 75% of age-predicted maximum heart rate (HR), and took a 150 mg capsule of EGCG (Teavigo) or placebo (lactose) twice daily for 12 weeks. Blood parameters (lipids, glucose and insulin), blood pressure, heart rate, arterial function and anthropometry were assessed at 0, 6 and 12 wk. At wk 0 and 12, body composition was assessed by dual energy X-ray absorptiometry (DXA) and abdominal fat was assessed by DXA and computed tomography (CT). RESULTS: Waist circumference (p < 0.01), total body fat (p < 0.02), abdominal fat (by DXA) (p < 0.01) and intra abdominal adipose tissue (by CT) (p < 0.01) were reduced in both treatment groups, with no difference between placebo and Teavigo. Teavigo significantly decreased resting HR (p < 0.01) and reduced plasma glucose in subjects with impaired glucose tolerance (p < 0.05). CONCLUSIONS: Moderate consumption of EGCG can improve the health status of overweight individuals undergoing regular exercise by reducing HR and plasma glucose concentrations. Loss of body fat, however, may require a higher intake of EGCG, other catechins or addition of metabolic stimulants. |
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Authors:
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Alison M Hill; Alison M Coates; Jonathan D Buckley; Robert Ross; Frank Thielecke; Peter R C Howe |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 26 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2007-12-03 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 396S-402S Citation Subset: IM |
Affiliation:
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ATN Centre for Metabolic Fitness, School of Health Sciences University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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drug effects*,
metabolism* Aged Blood Glucose / drug effects, metabolism Body Composition / drug effects*, physiology Body Mass Index Catechin / analogs & derivatives*, therapeutic use Dietary Supplements Female Health Status Heart Rate / drug effects, physiology Humans Middle Aged Obesity / therapy* Overweight / therapy Postmenopause / metabolism Treatment Outcome Waist-Hip Ratio Walking / physiology* Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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