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Can Colonic Manometry Studies be Done on the Day of Colonic Motility Catheter Placement?
MedLine Citation:
PMID:  22258291     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Colonic manometry has been used to assess colonic neuromuscular integrity in pediatric patients with severe constipation unresponsive to standard medical therapy and to tailor their treatment plans. There are currently no available standard protocols for conducting colonic manometry studies. AIMS:: To determine whether colonic manometry studies can be conducted on the same day the colonic motility catheters are placed and to compare the effects of inhaled sevoflurane versus intravenous propofol, used during catheter placement, on colonic motility. METHODS:: Twenty patients, randomized to receive sevoflurane or propofol during catheter placement, underwent colonic manometry on the day of catheter placement as well as the day after. The total motility index (MI), change in MI in response to a meal and bisacodyl, and presence of high amplitude propagating contractions (HAPCs) were compared between the two studies for each patient. RESULTS:: Ten patients were allocated to sevoflurane and ten patients to propofol. Eight (80%) patients in the sevoflurane group and nine (90%) patients in the propofol group had no differences in their studies between day 1 and 2 when the tracings were interpreted manually for gross evidence of HAPCs and gastrocolonic reflex. Similarly, there was no change in the total MI between studies done on day 1 and 2 in either sevoflurane (978 ± 232 vs. 978 ± 184; p = 0.99) or propofol (968 ± 200 vs. 1078 ± 227; p = 0.29) group. When comparing change in MI in response to a meal or bisacodyl between the two days, there was no statistical difference noted in either group. CONCLUSION:: Colonic manometry studies can be conducted as early as four hours following catheter placement with either propofol or sevoflurane used for anesthesia.
Rana F Ammoury; John D Emhardt; William B Aitchison; Debra S Horn; Joseph M Croffie
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-17
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Indiana University School of Medicine, Indianapolis, IN †Division of Anesthesiology, Indiana University School of Medicine, Indianapolis, IN 1Designed the research study, performed the research, analyzed the data and wrote the paper. 2Designed the research study, wrote the paper. 3Performed the research. 4Performed the research. 5Designed the research study, performed the research, analyzed the data and wrote the paper.
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