Document Detail


Can the CAMCOG be a good cognitive test for patients with Alzheimer's disease with low levels of education?
MedLine Citation:
PMID:  20678300     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The Cambridge Cognitive Examination (CAMCOG) is a useful test in screening for Alzheimer's disease (AD). However, the interpretation of CAMCOG cut-off scores is problematic and reference values are needed for different educational strata. Given the importance of earlier diagnoses of mild dementia, new cut-off values are required which take into account patients with low levels of education. This study aims to evaluate whether the CAMCOG can be used as an accurate screening test among AD patients and normal controls with different educational levels.
METHODS: Cross-sectional assessment was undertaken of 113 AD and 208 elderly controls with heterogeneous educational levels (group 1: 1-4 years; group 2: 5-8 years; and group 3: ≥ 9 years) from a geriatric clinic. submitted to a thorough diagnostic evaluation for AD including the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX). Controls had no cognitive or mood complaints. Sensitivity (SE) and specificity (SP) for the CAMCOG in each educational group was assessed with receiver-operator-characteristic (ROC) curves.
RESULTS: CAMCOG mean values were lower when education was reduced in both diagnostic groups (controls - group 1: 87; group 2: 91; group 3: 96; AD - group 1: 63; group 2: 62; group 3: 77). Cut-off scores for the three education groups were 79, 80 and 90, respectively. SE and SP varied among the groups (group 1: 88.1% and 83.5%; group 2: 84.6% and 96%; group 3: 70.8% and 90%).
CONCLUSION: The CAMCOG can be used as a cognitive test for patients with low educational level with good accuracy. Patients with higher education showed lower scores than previously reported.
Authors:
Ivan Aprahamian; José Eduardo Martinelli; Juliana Cecato; Rafael Izbicki; Mônica Sanches Yassuda
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2010-08-03
Journal Detail:
Title:  International psychogeriatrics / IPA     Volume:  23     ISSN:  1741-203X     ISO Abbreviation:  Int Psychogeriatr     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-07     Completed Date:  2011-07-26     Revised Date:  2012-08-08    
Medline Journal Info:
Nlm Unique ID:  9007918     Medline TA:  Int Psychogeriatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  96-101     Citation Subset:  IM    
Affiliation:
Psychogeriatric Unit, Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil. ivan.aprahamian@terra.com.br
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / diagnosis*
Cognition
Cross-Sectional Studies
Early Diagnosis
Educational Status
Female
Humans
Male
Mass Screening
Neuropsychological Tests*
Sensitivity and Specificity
Comments/Corrections
Comment In:
Int Psychogeriatr. 2012 Aug;24(8):1359-60; author reply 1360-1   [PMID:  22436203 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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