| Can 8-oxo-dG be used as a predictor for individual radiosensitivity? | |
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MedLine Citation:
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PMID: 11380227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To develop predictive tests for individual radiosensitivity of tumor patients. METHODS AND MATERIALS: Acute skin reactions were clinically scored among 40 women after 46 Gy, given with 2 Gy fractions to breast and regional lymph nodes, adjuvant after surgery. The acute skin reactions were compared to the excretion of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) in urine, determined by high-performance liquid chromatography (HPLC) with electrochemical detector. Specimens of urine were collected before and during postoperative radiation treatment at given intervals. We compared a group of 9 patients with the most pronounced skin reactions with another group of 8 patients with almost no skin reactions at 46 Gy. RESULTS: The level of 8-oxo-dG excreted in urine during 8 h was measured. After normalizing the excretion to irradiated volumes, dose per volume and excretion before irradiation, the 8-oxo-dG level in urine was significantly (p < 0.001) lower for the patients with pronounced skin reactions as compared to patients with minor skin reactions, at an accumulated dose of 12 Gy. In addition, the background level of 8-oxo-dG excreted before treatment started, was significantly (p = 0.043) lower for patients with minor skin reactions as compared to patients with pronounced skin reactions. The background level of 8-oxo-dG was corrected for body weight and normalized to BMI. CONCLUSION: We suggest that the excretion of 8-oxo-dG into urine of breast cancer patients is a possible marker for acute radiosensitivity. |
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Authors:
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S Haghdoost; P Svoboda; I Näslund; M Harms-Ringdahl; A Tilikides; S Skog |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 50 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-06-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 405-10 Citation Subset: IM |
Affiliation:
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Department of Radiotherapy, Radiumhemmet, Stockholm, Sweden. Siamak.haghdoost@ks.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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urine Breast Neoplasms / radiotherapy*, surgery, urine* Deoxyguanosine / analogs & derivatives*, urine* Dose-Response Relationship, Radiation Female Humans Predictive Value of Tests Radiation Tolerance / physiology* Radiodermatitis / urine Radiotherapy, Adjuvant Skin / radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 88847-89-6/8-oxo-7-hydrodeoxyguanosine; 961-07-9/Deoxyguanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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