Document Detail

Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes.
MedLine Citation:
PMID:  18225954     Owner:  NLM     Status:  MEDLINE    
Campylobacter jejuni is one of the major causes of infectious diarrhea world-wide, although relatively little is know about its mechanisms of pathogenicity. This bacterium can gain entry into intestinal epithelial cells, which is thought to be important for its ability to persistently infect and cause disease. We found that C. jejuni is able to survive within intestinal epithelial cells. However, recovery of intracellular bacteria required pre-culturing under oxygen-limiting conditions, suggesting that C. jejuni undergoes significant physiological changes within the intracellular environment. We also found that in epithelial cells the C. jejuni-containing vacuole deviates from the canonical endocytic pathway immediately after a unique caveolae-dependent entry pathway, thus avoiding delivery into lysosomes. In contrast, in macrophages, C. jejuni is delivered to lysosomes and consequently is rapidly killed. Taken together, these studies indicate that C. jejuni has evolved specific adaptations to survive within host cells.
Robert O Watson; Jorge E Galán
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  PLoS pathogens     Volume:  4     ISSN:  1553-7374     ISO Abbreviation:  PLoS Pathog.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-29     Completed Date:  2008-02-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101238921     Medline TA:  PLoS Pathog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e14     Citation Subset:  IM    
Section of Microbial Pathogenesis, Yale University, School of Medicine, New Haven, Connecticut, United States of America.
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MeSH Terms
Adaptation, Physiological / physiology*
COS Cells
Campylobacter jejuni / pathogenicity*,  physiology
Caveolae / microbiology
Caveolin 1 / metabolism
Cercopithecus aethiops
Endocytosis / physiology*
Epithelial Cells / metabolism,  microbiology*
Gene Expression Regulation, Bacterial
Intestinal Mucosa / metabolism,  microbiology*
Lysosomes / metabolism,  microbiology*
Macrophages / metabolism,  microbiology
Reg. No./Substance:
0/Caveolin 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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