Document Detail


Campylobacter jejuni--microtubule-dependent invasion.
MedLine Citation:
PMID:  11514222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Campylobacter jejuni is the leading bacterial cause of food-borne illness worldwide and a major cause of Guillain-Barré paralysis. Recent molecular and cellular studies of one well-characterized C. jejuni strain have begun to unravel the details of an unusual microtubule-dependent (actin-filament-independent) gut-invasion mechanism, through which at least some C. jejuni initiate disease. Although responsible for causing a human dysenteric syndrome remarkably similar to that triggered by Shigella spp., current evidence suggests that C. jejuni use some markedly different molecular mechanisms of pathogenesis compared with shigellae.
Authors:
D J Kopecko; L Hu; K J Zaal
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in microbiology     Volume:  9     ISSN:  0966-842X     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-11-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
Affiliation:
Laboratory of Enteric and Sexually Transmitted Diseases, FDA-Center for Biologics Evaluation and Research, Bldg 29/420, NIH Campus, Bethesda, MD 20892, USA. kopecko@cber.fda.gov
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MeSH Terms
Descriptor/Qualifier:
Campylobacter Infections / microbiology*
Campylobacter jejuni / genetics,  pathogenicity*
Dysentery, Bacillary / microbiology
Epithelial Cells / microbiology
Humans
Intestines / cytology,  microbiology
Microtubules / microbiology*,  physiology
Virulence

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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