| Campylobacter-associated Guillain-Barré syndrome after orthotopic liver transplantation for hepatitis C cirrhosis: a case report. | |
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MedLine Citation:
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PMID: 12270750 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Guillain-Barré syndrome is characterized by acute paralysis and ascending neuropathy due to an inflammatory attack on the myelin of peripheral nerves. About 2/3 of patients with Guillain-Barré syndrome have an infection 1-3 weeks before the onset of the symptoms. Guillain-Barré syndrome has rarely been reported after solid organ transplantation (18 cases with three cases after liver transplantation), and these cases are mostly related to a CMV infection. We describe a 64-year-old male patient who developed Guillain-Barré syndrome related to a Campylobacter fetus enteritis, 70 days post liver transplantation. Although the patient received tacrolimus as immunosuppressant agent and is hepatitis C positive, we can conclude that the Campylobacter infection was probably the primary trigger for the development of Guillain-Barré syndrome. As T-cell response is depressed in our patient and cross-reactive antibodies (anti-ganglioside GM-1) exists after Campylobacter infection, we suppose that a humorally mediated attack is responsible for Guillain-Barré syndrome after solid organ transplantation. A review of the literature is performed. |
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Authors:
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Isabelle Colle; Hans Van Vlierberghe; Roberto Troisi; Katrien De Ridder; Dominique Benoit; Bernard de Hemptinne; Martine De Vos |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: 24 ISSN: - ISO Abbreviation: Hepatol. Res. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-Sep-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9711801 Medline TA: Hepatol Res Country: - |
Other Details:
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Languages: ENG Pagination: 205 Citation Subset: - |
Affiliation:
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Department of Hepato-Gastroenterology, Ghent University Hospital, De Pintelaan 185, 9000, Gent, Belgium |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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