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Camptothecin: A Promising Antiretroviral Drug.
MedLine Citation:
PMID:  11725078     Owner:  NLM     Status:  Publisher    
The plant alkaloid camptothecin (CPT) has demonstrated the ability to inhibit replication of the equine anemia virus (E1AV) and the human immunodeficiency virus (HIV) in infected cells in culture. Further, CPT prevented the development of lymphoma and erythroleukemia in mice infected with the Moloney murine leukemia virus and the Friend erythroleukemia virus, respectively, as assessed by prevention or reduction of splenomegaly. These results were observed at concentrations that had no apparent toxic effects on the mice. It has been suggested that the antiretroviral activity of CPT is mediated by the host cell's enzyme topoisomerase I. Taken collectively, the findings indicate that CPT analogues may develop into potent drugs against various human and animal diseases caused by diverse retroviruses. Copyright 1996 S. Karger AG, Basel
P. Pantazis
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Publication Detail:
Journal Detail:
Title:  Journal of biomedical science     Volume:  3     ISSN:  1423-0127     ISO Abbreviation:  J. Biomed. Sci.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  2001-Nov-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421567     Medline TA:  J Biomed Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  14-19     Citation Subset:  -    
The Stehlin Foundation for Cancer Research at St. Joseph Hospital, Houston, Tex., USA.
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