Document Detail


Cambendazole and nondrug macromolecules in tissue residues.
MedLine Citation:
PMID:  853544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anthelmintic cambendazole is rapidly metabolized to at least 13 urinary metabolites. Radioactivity was found in liver for weeks after a single dose in cattle, but even at 3 days' withdrawal, cambendazole and metabolites previously identified in urine accounted for only a small fraction of liver radioactivity. The radioactivity was ubiquitously distributed in protein and nucleic acid fractions, and [14C] glutamic acid was identified, indicating incorporation of 14C into the endogenous pool. Part of the residual liver radioactivity at 7 days was convertible chemically to 5-nitrobenzimidazole, indicating a drug-related macromolecular residue. However, data from rats fed radiolabeled steer liver indicate that the residue is minimally bioavailable and therefore of substantially less toxicological concern than cambendazole itself.
Authors:
J E Baer; T A Jacob; F J Wolf
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  2     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  895-903     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzimidazoles / metabolism*
Biological Availability
Cambendazole / analysis,  chemical synthesis,  metabolism*
Cattle
Chemical Phenomena
Chemistry
Glutamates / metabolism
Liver / metabolism
Sheep
Time Factors
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Glutamates; 26097-80-3/Cambendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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