Document Detail

Calvarial defects associated with neurofibromatosis type 1. Report of two cases.
MedLine Citation:
PMID:  17566407     Owner:  NLM     Status:  MEDLINE    
Calvarial osteolysis is a relatively rare finding in patients with neurofibromatosis. The authors describe two patients with neurofibromatosis Type 1 (NF1) and extensive cranial defects associated with underlying dural ectasia. Cranioplasties were performed in both patients with mixed results. One patient underwent cranioplasty using titanium mesh and methylmethacrylate. The other patient underwent an extensive cranioplasty with autogenous iliac crest grafting, and after initial healing has since had further bone resorption. In conclusion, the results of cranial reconstruction in patients with NF1 and dural ectasia are unpredictable because of the tendency for further bone resorption; techniques that protect the graft material from cerebrospinal fluid pulsations via a rigid mesh should be considered.
John M K Mislow; Mark R Proctor; P Daniel McNeely; Arin K Greene; Gary F Rogers
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  106     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-14     Completed Date:  2007-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  484-9     Citation Subset:  AIM; IM    
Department of Neurosurgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
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MeSH Terms
Absorbable Implants
Bone Plates
Head / radiography
Ilium / transplantation
Imaging, Three-Dimensional
Neurofibromatosis 1 / complications*
Neurosurgical Procedures*
Osteolysis / etiology*,  radiography,  surgery*
Skull* / radiography
Surgical Mesh
Tomography, X-Ray Computed
Reg. No./Substance:

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