Document Detail


Calvarial defects associated with neurofibromatosis type 1. Report of two cases.
MedLine Citation:
PMID:  17566407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calvarial osteolysis is a relatively rare finding in patients with neurofibromatosis. The authors describe two patients with neurofibromatosis Type 1 (NF1) and extensive cranial defects associated with underlying dural ectasia. Cranioplasties were performed in both patients with mixed results. One patient underwent cranioplasty using titanium mesh and methylmethacrylate. The other patient underwent an extensive cranioplasty with autogenous iliac crest grafting, and after initial healing has since had further bone resorption. In conclusion, the results of cranial reconstruction in patients with NF1 and dural ectasia are unpredictable because of the tendency for further bone resorption; techniques that protect the graft material from cerebrospinal fluid pulsations via a rigid mesh should be considered.
Authors:
John M K Mislow; Mark R Proctor; P Daniel McNeely; Arin K Greene; Gary F Rogers
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  106     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-14     Completed Date:  2007-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  484-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurosurgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. jmislow@partners.org
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MeSH Terms
Descriptor/Qualifier:
Absorbable Implants
Adolescent
Bone Plates
Female
Head / radiography
Humans
Ilium / transplantation
Imaging, Three-Dimensional
Male
Neurofibromatosis 1 / complications*
Neurosurgical Procedures*
Osteolysis / etiology*,  radiography,  surgery*
Skull* / radiography
Surgical Mesh
Titanium
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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