Document Detail


Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9.
MedLine Citation:
PMID:  23772398     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
A majority of small cell lung cancer (SCLC) cells lack a metastasis suppressor, tetraspanin CD9, and CD9 expression promotes their apoptosis. By a proteomics-based approach, we compared an SCLC cell line with its CD9 transfectant and found that a calcium-binding neuronal protein, calretinin, is upregulated in CD9-positive SCLC cells. Ectopic or anticancer drug-induced CD9 expression upregulated calretinin, whereas CD9 knockdown down-regulated calretinin in SCLC cells. When calretinin was knocked down, CD9-positive SCLC cells revealed increased Akt phosphorylation and decreased apoptosis. These results suggest that CD9 positively regulates the expression of calretinin that mediates proapoptotic effect in SCLC cells.
Authors:
Ping He; Hanako Kuhara; Isao Tachibana; Yingji Jin; Yoshito Takeda; Satoshi Tetsumoto; Toshiyuki Minami; Satoshi Kohmo; Haruhiko Hirata; Ryo Takahashi; Koji Inoue; Izumi Nagatomo; Hiroshi Kida; Takashi Kijima; Tetsuji Naka; Eiichi Morii; Ichiro Kawase; Atsushi Kumanogoh
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Publication Detail:
Type:  Journal Article     Date:  2013-05-10
Journal Detail:
Title:  FEBS open bio     Volume:  3     ISSN:  2211-5463     ISO Abbreviation:  FEBS Open Bio     Publication Date:  2013  
Date Detail:
Created Date:  2013-06-17     Completed Date:  2013-06-18     Revised Date:  2013-06-21    
Medline Journal Info:
Nlm Unique ID:  101580716     Medline TA:  FEBS Open Bio     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  -    
Affiliation:
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan ; Department of Respiratory Medicine, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 71004, China.
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