| Calponin expression in laryngeal myoepithelial carcinoma and its prognostic implications: a case report and literature review. | |
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MedLine Citation:
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PMID: 20515587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case report of laryngeal myoepithelial carcinoma (MEC) is presented and the literature concerning prognostic factors in MEC is reviewed. A 61-year old man was admitted to hospital with hoarseness and progressive dyspnoea. On examination, both vocal cords were fixed in the midline with a glottic fissure of only 3 mm. No tumour was seen, but the subglottis was not completely visible. A computed tomography scan showed a soft mass below the right vocal cord obstructing two-thirds of the larynx. On suspension laryngoscopy, a dull mass (1.5 x 1.5 cm) was seen below the right vocal cord, which was malignant on frozen biopsy. A total laryngectomy was performed and the patient received radiotherapy. He died of recurrence 25 months later. The tumour was positive for cytokeratin 14, S-100 protein and calponin. MEC of the larynx is extremely rare. The clinical behaviour of MEC is variable and prognostic factors have been poorly analysed. Calponin expression may be a prognostic factor, but other factors also affect the outcome in MEC. |
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Authors:
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Y J Mao; X M Luo; S H Zhou; Z J Zheng |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The Journal of international medical research Volume: 38 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-07-15 Revised Date: 2011-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 711-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcium-Binding Proteins
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metabolism* Humans Immunoenzyme Techniques Laryngeal Neoplasms / metabolism*, radiotherapy, surgery Laryngectomy Male Microfilament Proteins / metabolism* Middle Aged Myoepithelioma / metabolism*, radiotherapy, surgery Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Proteins; 0/Microfilament Proteins; 0/Tumor Markers, Biological; 0/calponin |
| Comments/Corrections | |
Erratum In:
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J Int Med Res. 2011;39(4):1570-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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