| Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis. | |
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MedLine Citation:
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PMID: 20623621 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental autoimmune encephalomyelitis (EAE) is an animal model for studying multiple sclerosis (MS). Calpain has been implicated in many inflammatory and neurodegenerative events that lead to disability in EAE and MS. Thus, treating EAE animals with calpain inhibitors may block these events and ameliorate disability. To test this hypothesis, acute EAE Lewis rats were treated dose dependently with the calpain inhibitor calpeptin (50-250 microg/kg). Calpain activity, gliosis, loss of myelin, and axonal damage were attenuated by calpeptin therapy, leading to improved clinical scores. Neuronal and oligodendrocyte death were also decreased, with down-regulation of proapoptotic proteins, suggesting that decreases in cell death were due to decreases in the expression or activity of proapoptotic proteins. These results indicate that calpain inhibition may offer a novel therapeutic avenue for treating EAE and MS. |
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Authors:
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M Kelly Guyton; Arabinda Das; Supriti Samantaray; Gerald C Wallace; Jonathan T Butler; Swapan K Ray; Naren L Banik |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of neuroscience research Volume: 88 ISSN: 1097-4547 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-13 Completed Date: 2010-10-20 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
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Languages: eng Pagination: 2398-408 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / drug effects*, pathology* Blotting, Western Calpain / antagonists & inhibitors Cell Death / drug effects* Cysteine Proteinase Inhibitors / pharmacology* Dipeptides / pharmacology* Down-Regulation / physiology Encephalomyelitis, Autoimmune, Experimental / drug therapy*, pathology* Fluorescent Antibody Technique Gliosis / chemically induced, pathology In Situ Nick-End Labeling Inflammation / pathology, prevention & control* Male Multiple Sclerosis / drug therapy*, pathology* Nerve Tissue Proteins / biosynthesis Oligodendroglia / pathology Rats Rats, Inbred Lew Spinal Cord / pathology Tissue Embedding |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR015455-01A1/RR/NCRR NIH HHS; C06RR-015455/RR/NCRR NIH HHS; CA-91460/CA/NCI NIH HHS; NS-38146/NS/NINDS NIH HHS; NS-41088/NS/NINDS NIH HHS; NS-56176/NS/NINDS NIH HHS; NS-57811/NS/NINDS NIH HHS; R01 NS038146-05/NS/NINDS NIH HHS; R01 NS041088-07/NS/NINDS NIH HHS; R01 NS056176-05/NS/NINDS NIH HHS; R01 NS057811-04/NS/NINDS NIH HHS; R01 NS065456-03/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cysteine Proteinase Inhibitors; 0/Dipeptides; 0/Nerve Tissue Proteins; 117591-20-5/calpeptin; EC 3.4.22.-/Calpain |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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