Document Detail


Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.
MedLine Citation:
PMID:  8633033     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many studies of caloric restriction (CR) in rodents and lower animals indicate that this nutritional manipulation retards aging processes, as evidenced by increased longevity, reduced pathology, and maintenance of physiological function in a more youthful state. The anti-aging effects of CR are believed to relate, at least in part, to changes in energy metabolism. We are attempting to determine whether similar effects occur in response to CR in nonhuman primates. Core (rectal) body temperature decreased progressively with age from 2 to 30 years in rhesus monkeys fed ad lib (controls) and is reduced by approximately 0.5 degrees C in age-matched monkeys subjected to 6 years of a 30% reduction in caloric intake. A short-term (1 month) 30% restriction of 2.5-year-old monkeys lowered subcutaneous body temperature by 1.0 degrees C. Indirect calorimetry showed that 24-hr energy expenditure was reduced by approximately 24% during short-term CR. The temporal association between reduced body temperature and energy expenditure suggests that reductions in body temperature relate to the induction of an energy conservation mechanism during CR. These reductions in body temperature and energy expenditure are consistent with findings in rodent studies in which aging rate was retarded by CR, now strengthening the possibility that CR may exert beneficial effects in primates analogous to those observed in rodents.
Authors:
M A Lane; D J Baer; W V Rumpler; R Weindruch; D K Ingram; E M Tilmont; R G Cutler; G S Roth
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  93     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-07-01     Completed Date:  1996-07-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4159-64     Citation Subset:  IM    
Affiliation:
Molecular Physiology and Genetics Section, Nathan W. Shock Laboratories, National Institute on Aging, National Institutes of Health, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Analysis of Variance
Animals
Body Mass Index
Body Temperature*
Calorimetry, Indirect
Circadian Rhythm
Diet, Reducing*
Energy Intake
Energy Metabolism
Macaca mulatta
Male
Regression Analysis
Rodentia
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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