Document Detail

Calorie restriction and the exercise of chromatin.
MedLine Citation:
PMID:  19608767     Owner:  NLM     Status:  MEDLINE    
Since the earliest stages of evolution, organisms have faced the challenge of sensing and adapting to environmental changes for their survival under compromising conditions such as food depletion or stress. Implicit in these responses are mechanisms developed during evolution that include the targeting of chromatin to allow or prevent expression of fundamental genes and to protect genome integrity. Among the different approaches to study these mechanisms, the analysis of the response to a moderate reduction of energy intake, also known as calorie restriction (CR), has become one of the best sources of information regarding the factors and pathways involved in metabolic adaptation from lower to higher eukaryotes. Furthermore, responses to CR are involved in life span regulation-conserved from yeast to mammals-and therefore have garnered major research interest. Herein we review current knowledge of responses to CR at the molecular level and their functional link to chromatin.
Alejandro Vaquero; Danny Reinberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-07-16
Journal Detail:
Title:  Genes & development     Volume:  23     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-08-28     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1849-69     Citation Subset:  IM    
Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program (PEBC), ICREA, and IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
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MeSH Terms
Caloric Restriction*
Chromatin / metabolism*
Enzymes / metabolism
Mitochondria / metabolism
Reactive Oxygen Species / metabolism
Sirtuins / metabolism
Transcription Factors / metabolism
Grant Support
//Howard Hughes Medical Institute
Reg. No./Substance:
0/Chromatin; 0/Enzymes; 0/Reactive Oxygen Species; 0/Transcription Factors; EC 3.5.1.-/Sirtuins

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