Document Detail

Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse.
MedLine Citation:
PMID:  2337899     Owner:  NLM     Status:  MEDLINE    
Two experiments have been conducted to determine the effects of calorie restriction on cellular proliferation in female mouse tissues. In the first experiment, 25% calorie restriction led to a decrease in cellular proliferation, measured by the [3H]thymidine labeling index, in each of the 7 tissues examined. The duct lining cells of the mammary gland were the most affected. This conclusion was confirmed in the second experiment in which levels of 0, 10, 20, 30 and 40% calorie restriction were employed. The difference in response of the duct cells of the mammary gland and the crypt cells of the colo-rectum is discussed in light of the opinion that the formation of cancer of these tissues in humans may be markedly affected by diet.
E Lok; F W Scott; R Mongeau; E A Nera; S Malcolm; D B Clayson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  51     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-20     Completed Date:  1990-06-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-73     Citation Subset:  IM    
Toxicology Research Division, Health and Welfare Canada, Banting Research Centre, Ottawa, Ontario.
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MeSH Terms
Analysis of Variance
Animal Feed
Animal Nutritional Physiological Phenomena*
Body Weight
Cell Division*
Esophagus / cytology
Intestines / cytology
Mammary Glands, Animal / cytology
Mitotic Index
Skin / cytology
Urinary Bladder / cytology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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