| Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine. | |
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MedLine Citation:
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PMID: 22086353 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Although caloric restriction (CR) apparently has beneficial effects on the immune system, its effects on the immunological function of the intestinal mucosa are little known. The present study explored the effect of CR on the innate and adaptive intestinal immunity of mice. Balb/c mice were either fed ad libitum (control) or on alternate days fed ad libitum and fasted (caloric restriction). After 4 months, an evaluation was made of IgA levels in the ileum, the gene expression for IgA and its receptor (pIgR), as well as the expression of two antimicrobial enzymes (lysozyme and phospholipase A2) and several cytokines of the intestinal mucosa. CR increased the gene expression of lysozyme and phospholipase A2. The levels of IgA were diminished in the ileum, which apparently was a consequence of the reduced transport of IgA by pIgR. In ileum, CR increased the gene expression for most cytokines, both pro- and anti-inflammatory. Hence, CR differentially modified the expression of innate and adaptive immunity mediators in the intestine. |
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Authors:
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María Antonieta Suárez-Souto; Eleazar Lara-Padilla; Humberto Reyna-Garfias; María Viloria; Pedro López-Sánchez; Víctor Rivera-Aguilar; Angel Miliar-García; Alexander Kormanovski; María Lilia Domínguez-López; Rafael Campos-Rodríguez |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: Journal of physiology and biochemistry Volume: - ISSN: 1877-8755 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812509 Medline TA: J Physiol Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala s/n, CP 11340, Mexico City, DF, México. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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