Document Detail

Caloric restriction lowers blood pressure in the spontaneously hypertensive rat.
MedLine Citation:
PMID:  723627     Owner:  NLM     Status:  MEDLINE    
In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto--WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.
J B Young; D Mullen; L Landsberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  27     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-02-12     Completed Date:  1979-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1711-4     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Diet, Reducing*
Disease Models, Animal
Energy Intake*
Hypertension / genetics,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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