Document Detail

Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans.
MedLine Citation:
PMID:  16858629     Owner:  NLM     Status:  MEDLINE    
Calorie restriction is known to increase lifespan in many but not all species and may perhaps not do so in humans. Exceptions to life extension have been identified in the laboratory and others are known in nature. Given the variety of physiological responses to variation in food supply that are possible, evolutionary life history theory indicates that an increased investment in maintenance in response to resource shortage will not always be the strategy that maximises Darwinian fitness. Additionally, for the well-studied species in which life extension is observed, there is considerable variation in the response. This suggests that it is not an ancient ancestral response, which has been conserved across the species range. Although calorie restriction does not increase lifespan in all species, it remains a fascinating and valuable tool to study ageing at the whole organism level.
Daryl P Shanley; Thomas B L Kirkwood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biogerontology     Volume:  7     ISSN:  1389-5729     ISO Abbreviation:  Biogerontology     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930043     Medline TA:  Biogerontology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  165-8     Citation Subset:  IM    
Henry Wellcome Laboratory for Biogerontology Research, School of Clinical and Medical Sciences-Gerontology, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK.
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MeSH Terms
Aging / physiology*
Caloric Restriction*
Eating / physiology*
Longevity / physiology*
Models, Biological*
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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