| Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 18593278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caloric restriction (CR) decreases circulating triiodothyronine (T(3)) concentration. However, it is not known if this effect is due to body fat mass reductions or due to CR, per se. The purpose of this study was to test the hypothesis that plasma T(3) concentration decreases with CR-induced reductions in fat mass but not in response to similar decreases in fat mass that are induced by exercise. Sedentary, nonobese 50- to 60-year-old men and women with no clinical evidence of cardiovascular or metabolic disease and not taking thyroid medications were randomly assigned to 12 months of caloric restriction (n = 18) or exercise-induced weight loss (n = 17) or to a control group (n = 9). Body weight and composition and plasma concentrations of the thyroid hormones T(3), thyrotropin (TSH), thyroxine (T(4)), and free thyroxine (FT(4)) were measured at baseline and 12 months. Fat mass changed significantly in the CR (-6.3 +/- 1.0 kg) and exercise (-5.5 +/- 1.0 kg) groups but not in the control group (-0.6 +/- 1.4 kg). The changes were not significantly different between the CR and exercise groups. Plasma T(3) concentration decreased in the CR group (-9.8 +/- 2.0 ng/dL, p < 0.0001) but not in the exercise (-3.8 +/- 2.1 ng/dL, p = 0.07) or control (-1.3 +/- 2.8 ng/dL, p = 0.65) groups. TSH, T(4), and FT(4) did not change in any of the study groups. Twelve months of CR decreased circulating T(3) concentrations in middle-aged adults. This effect does not appear to be attributable to changes in body fat mass because a comparable decrease in T(3) concentration was not observed in response to an exercise-induced fat mass reduction. |
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Authors:
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Edward P Weiss; Dennis T Villareal; Susan B Racette; Karen Steger-May; Bhartur N Premachandra; Samuel Klein; Luigi Fontana |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rejuvenation research Volume: 11 ISSN: 1549-1684 ISO Abbreviation: Rejuvenation Res Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-08-21 Revised Date: 2011-02-21 |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 605-9 Citation Subset: IM |
Affiliation:
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Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA. eweiss4@slu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Body Weight Caloric Restriction* Dietary Carbohydrates / administration & dosage Exercise* Female Humans Male Middle Aged Thyroglobulin / blood Triiodothyronine / blood* |
| Grant Support | |
ID/Acronym/Agency:
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AG 00078/AG/NIA NIH HHS; AG 20487/AG/NIA NIH HHS; DK 56341/DK/NIDDK NIH HHS; M01 RR000036-47/RR/NCRR NIH HHS; P30 DK056341-08/DK/NIDDK NIH HHS; RR 00036/RR/NCRR NIH HHS; T32 AG000078-24/AG/NIA NIH HHS; U01 AG020487-07/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 6893-02-3/Triiodothyronine; 9010-34-8/Thyroglobulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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