| Caloric restriction, aerobic exercise training and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese post-menopausal women. | |
| | |
MedLine Citation:
|
PMID: 20856256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Elevated circulating levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) have been observed in obese persons and are reduced by weight loss. However, it is not known whether combining caloric restriction (CR) with exercise training is better in reducing sLOX-1 levels than CR alone. OBJECTIVE: We examined whether the addition of aerobic exercise to a weight loss intervention differentially affects sLOX-1 levels in 61 abdominally obese post-menopausal women randomly assigned to a CR only (n = 22), CR+moderate-intensity exercise (n = 22) or CR+vigorous-intensity exercise (n = 17) intervention for 20 weeks. The caloric deficit was ~2800 kcal per week for all groups.Results:The intervention groups were similar at baseline with respect to body weight, body composition, lipids and blood pressure. However, plasma sLOX-1 levels were higher in the CR-only group (99.90 ± 8.23 pg ml(-1)) compared with both the CR+moderate-intensity exercise (69.39 ± 8.23 pg ml(-1), P = 0.01) and the CR+vigorous-intensity exercise (72.83 ± 9.36 pg ml(-1), P = 0.03) groups. All three interventions significantly reduced body weight (~14%), body fat and waist and hip circumferences to a similar degree. These changes were accompanied by a 23% reduction in sLOX-1 levels overall (-19.00 ± 30.08 pg ml(-1), P < 0.0001), which did not differ among intervention groups (P = 0.13). Changes in body weight, body fat and maximal oxygen consumption (VO(2) max) were not correlated with changes in sLOX-1 levels. In multiple regression analyses in all women combined, baseline sLOX-1 levels (β = -0.70 ± 0.06, P < 0.0001), age (β = 0.92 ± 0.43, P = 0.03) and baseline body mass index (BMI) (β = 1.88 ± 0.66, P = 0.006) were independent predictors of the change in sLOX-1 with weight loss.Conclusions:Weight loss interventions of equal energy deficit have similar effects on sLOX-1 levels in overweight and obese post-menopausal women, with the addition of aerobic exercise having no added benefit when performed in conjunction with CR. |
| | |
Authors:
|
T E Brinkley; X Wang; N Kume; H Mitsuoka; B J Nicklas |
Related Documents
:
|
9803696 - Use of personal trainers and financial incentives to increase exercise in a behavioral ... 2020266 - Factors common to successful therapy for the obese patient. 15989416 - Electroacupuncture in obese women: a randomized, controlled pilot study. 8596486 - Contrasting effects of resistance and aerobic training on body composition and metaboli... 7476056 - Nitric oxide production and no synthase gene expression contribute to vascular regulati... 10735976 - Cardiac output measured by electric bioimpedance compared with the co2 rebreathing tech... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-09-21 |
Journal Detail:
|
Title: International journal of obesity (2005) Volume: 35 ISSN: 1476-5497 ISO Abbreviation: Int J Obes (Lond) Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-06-14 Completed Date: 2011-09-09 Revised Date: 2012-05-04 |
Medline Journal Info:
|
Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: England |
Other Details:
|
Languages: eng Pagination: 793-9 Citation Subset: IM |
Affiliation:
|
J Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. tbrinkle@wfubmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Body Mass Index Caloric Restriction / methods* Exercise* Exercise Therapy Female Humans Middle Aged Obesity, Abdominal / blood*, therapy Overweight / blood, therapy Postmenopause / blood* Receptors, Oxidized LDL / blood*, genetics Scavenger Receptors, Class E / blood*, genetics Weight Loss / genetics |
| Grant Support | |
ID/Acronym/Agency:
|
M01 RR007122-17/RR/NCRR NIH HHS; M01-RR07122/RR/NCRR NIH HHS; P30 AG021332-09/AG/NIA NIH HHS; P30-AG21332/AG/NIA NIH HHS; R01 AG020583-05/AG/NIA NIH HHS; R01 AG020583-08/AG/NIA NIH HHS; R01 HL093713/HL/NHLBI NIH HHS; R01-AG/DK20583/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Oxidized LDL; 0/Scavenger Receptors, Class E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in C-reactive protein during weight loss and the association with changes in anthropometric ...
Next Document: Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children.