Document Detail

Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity.
MedLine Citation:
PMID:  20861239     Owner:  NLM     Status:  MEDLINE    
Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia, insulin resistance, visceral obesity, and dyslipidemia. They also exhibit features of nonalcoholic steatohepatitis, including chicken-wire fibrosis, inflammation, and oxidative stress. Hyperinsulinemia in these rats is associated with impaired hepatic insulin clearance. The current studies aimed to determine whether these metabolic abnormalities could be reversed by caloric restriction (CR). CR by 30% over a period of 2-3 months improved insulin clearance in parallel to inducing the protein content and activation of the carcinoembryonic antigen-related cell adhesion molecule 1, a main player in hepatic insulin extraction. It also reduced glucose and insulin intolerance and serum and tissue (liver and muscle) triglyceride levels. Additionally, CR reversed inflammation, oxidative stress, and fibrosis in liver. The data support a significant role of CR in the normalization of insulin and lipid metabolism in liver.
Thomas A Bowman; Sadeesh K Ramakrishnan; Meenakshi Kaw; Sang Jun Lee; Payal R Patel; Varun K Golla; Raymond E Bourey; Per Magnus Haram; Lauren G Koch; Steven L Britton; Ulrik Wisløff; Abraham D Lee; Sonia M Najjar
Related Documents :
11693199 - Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxa...
1512029 - In vitro influence of hormones on transport of glucose and glycogen in liver and muscle...
1987849 - Glucose intolerance and hyperinsulinemia of cirrhosis are not results of spontaneous or...
10852599 - Regulation of glucose tolerance in patients after liver transplantation: impact of cycl...
3079759 - The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats.
17646659 - Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.
24482829 - Assessment of beta-cell function in young patients with type 2 diabetes: arginine-stimu...
21470009 - Adolescent bmi trajectory and risk of diabetes versus coronary disease.
3275549 - Effects of hypoglycemia on kindling seizures in suckling rats.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-09-22
Journal Detail:
Title:  Endocrinology     Volume:  151     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-11-04     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5157-64     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Blotting, Western
Caloric Restriction*
Fatty Liver / metabolism*,  pathology
Glucose / metabolism
Insulin / metabolism*
Insulin Resistance*
Lipid Metabolism
Liver / metabolism*,  pathology
Obesity / metabolism
Oxidative Stress
Physical Conditioning, Animal*
Random Allocation
Grant Support
Reg. No./Substance:
0/Insulin; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregul...
Next Document:  Estrogen stimulation of cell migration involves multiple signaling pathway interactions.