| Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. | |
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MedLine Citation:
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PMID: 20861239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia, insulin resistance, visceral obesity, and dyslipidemia. They also exhibit features of nonalcoholic steatohepatitis, including chicken-wire fibrosis, inflammation, and oxidative stress. Hyperinsulinemia in these rats is associated with impaired hepatic insulin clearance. The current studies aimed to determine whether these metabolic abnormalities could be reversed by caloric restriction (CR). CR by 30% over a period of 2-3 months improved insulin clearance in parallel to inducing the protein content and activation of the carcinoembryonic antigen-related cell adhesion molecule 1, a main player in hepatic insulin extraction. It also reduced glucose and insulin intolerance and serum and tissue (liver and muscle) triglyceride levels. Additionally, CR reversed inflammation, oxidative stress, and fibrosis in liver. The data support a significant role of CR in the normalization of insulin and lipid metabolism in liver. |
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Authors:
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Thomas A Bowman; Sadeesh K Ramakrishnan; Meenakshi Kaw; Sang Jun Lee; Payal R Patel; Varun K Golla; Raymond E Bourey; Per Magnus Haram; Lauren G Koch; Steven L Britton; Ulrik Wisløff; Abraham D Lee; Sonia M Najjar |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-09-22 |
Journal Detail:
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Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-04 Revised Date: 2013-03-05 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 5157-64 Citation Subset: AIM; IM |
Affiliation:
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Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, College of Medicine, University of Toledo, Toledo, Ohio 43614, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blotting, Western Caloric Restriction* Fatty Liver / metabolism*, pathology Fibrosis Glucose / metabolism Insulin / metabolism* Insulin Resistance* Lipid Metabolism Liver / metabolism*, pathology Male Obesity / metabolism Oxidative Stress Physical Conditioning, Animal* Random Allocation Rats |
| Grant Support | |
ID/Acronym/Agency:
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DK054254/DK/NIDDK NIH HHS; DK083850/DK/NIDDK NIH HHS; R24 RR017718-10/RR/NCRR NIH HHS; R24RR017718/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; 50-99-7/Glucose |
| Comments/Corrections | |
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