Document Detail


Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity.
MedLine Citation:
PMID:  20861239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia, insulin resistance, visceral obesity, and dyslipidemia. They also exhibit features of nonalcoholic steatohepatitis, including chicken-wire fibrosis, inflammation, and oxidative stress. Hyperinsulinemia in these rats is associated with impaired hepatic insulin clearance. The current studies aimed to determine whether these metabolic abnormalities could be reversed by caloric restriction (CR). CR by 30% over a period of 2-3 months improved insulin clearance in parallel to inducing the protein content and activation of the carcinoembryonic antigen-related cell adhesion molecule 1, a main player in hepatic insulin extraction. It also reduced glucose and insulin intolerance and serum and tissue (liver and muscle) triglyceride levels. Additionally, CR reversed inflammation, oxidative stress, and fibrosis in liver. The data support a significant role of CR in the normalization of insulin and lipid metabolism in liver.
Authors:
Thomas A Bowman; Sadeesh K Ramakrishnan; Meenakshi Kaw; Sang Jun Lee; Payal R Patel; Varun K Golla; Raymond E Bourey; Per Magnus Haram; Lauren G Koch; Steven L Britton; Ulrik Wisløff; Abraham D Lee; Sonia M Najjar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-09-22
Journal Detail:
Title:  Endocrinology     Volume:  151     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-11-04     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5157-64     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blotting, Western
Caloric Restriction*
Fatty Liver / metabolism*,  pathology
Fibrosis
Glucose / metabolism
Insulin / metabolism*
Insulin Resistance*
Lipid Metabolism
Liver / metabolism*,  pathology
Male
Obesity / metabolism
Oxidative Stress
Physical Conditioning, Animal*
Random Allocation
Rats
Grant Support
ID/Acronym/Agency:
DK054254/DK/NIDDK NIH HHS; DK083850/DK/NIDDK NIH HHS; R24 RR017718/RR/NCRR NIH HHS; R24 RR017718-10/RR/NCRR NIH HHS; R24RR017718/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Insulin; IY9XDZ35W2/Glucose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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