Document Detail

Calmodulin-related CML24 Interacts with ATG4b and Affects Autophagy Progression in Arabidopsis.
MedLine Citation:
PMID:  23039100     Owner:  NLM     Status:  Publisher    
Plants encounter environmental stress challenges distinct from those of other eukaryotes because of their relative non-mobility. Therefore, plants may have evolved distinct regulatory aspects of conserved cellular functions. Plants, like other eukaryotes, share aspects of both calcium and calmodulin-based cellular signaling and the autophagic process of cellular renewal. Here, we report a novel function for an Arabidopsis calmodulin-related protein, CML24, and insight into ATG4-regulated autophagy. CML24 interacts with ATG4b in yeast 2-hybrid, in vitro pull-down, and transient tobacco cell transformation assays. Mutants with missense mutations in CML24 have aberrant ATG4 activity patterns in in vitro extract assays, ATG8 accumulation levels, GFP-ATG8 decorated cellular structures, and darkness-induced starvation recovery. Together these results support the conclusion that CML24 affects autophagy progression through interactions with ATG4. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.
Yu-Chang Tsai; Yeonjong Koo; Nikkí A Delk; Bernadette Gehl; Janet Braam
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  The Plant journal : for cell and molecular biology     Volume:  -     ISSN:  1365-313X     ISO Abbreviation:  Plant J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9207397     Medline TA:  Plant J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.
Biochemistry and Cell Biology, Rice University, Houston, TX, 77005-1892.
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