| Calmodulin-related CML24 Interacts with ATG4b and Affects Autophagy Progression in Arabidopsis. | |
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MedLine Citation:
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PMID: 23039100 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Plants encounter environmental stress challenges distinct from those of other eukaryotes because of their relative non-mobility. Therefore, plants may have evolved distinct regulatory aspects of conserved cellular functions. Plants, like other eukaryotes, share aspects of both calcium and calmodulin-based cellular signaling and the autophagic process of cellular renewal. Here, we report a novel function for an Arabidopsis calmodulin-related protein, CML24, and insight into ATG4-regulated autophagy. CML24 interacts with ATG4b in yeast 2-hybrid, in vitro pull-down, and transient tobacco cell transformation assays. Mutants with missense mutations in CML24 have aberrant ATG4 activity patterns in in vitro extract assays, ATG8 accumulation levels, GFP-ATG8 decorated cellular structures, and darkness-induced starvation recovery. Together these results support the conclusion that CML24 affects autophagy progression through interactions with ATG4. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd. |
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Authors:
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Yu-Chang Tsai; Yeonjong Koo; Nikkí A Delk; Bernadette Gehl; Janet Braam |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-8 |
Journal Detail:
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Title: The Plant journal : for cell and molecular biology Volume: - ISSN: 1365-313X ISO Abbreviation: Plant J. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9207397 Medline TA: Plant J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd. |
Affiliation:
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Biochemistry and Cell Biology, Rice University, Houston, TX, 77005-1892. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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