Document Detail

Calmodulin infused intracerebroventricularly enhances food intake in the cat.
MedLine Citation:
PMID:  6850344     Owner:  NLM     Status:  MEDLINE    
In the fasted cat, calmodulin (CaM) infused into the cerebral ventricle produces an increase in the normal intake of food in a dose-dependent manner. The enhancement of feeding by CaM seems to be functionally specific since the response was: (1) abolished by the simultaneous intraventricular infusion of calcineurin, a specific CaM antagonist; (2) not mimicked by another calcium binding protein, troponin C; and (3) independent of the CaM's lack of effect on body temperature and water intake. This finding opens up the dual possibility that this Ca2+ binding protein may affect receptors other than intracellularly and that CaM is involved in specific functions controlled by the brain.
R D Myers; T F Lee; S E King
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  266     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
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MeSH Terms
Appetite / drug effects*
Calcium-Binding Proteins / pharmacology*
Calmodulin / administration & dosage,  pharmacology*
Cerebral Ventricles / drug effects,  physiology
Feeding Behavior / drug effects*
Injections, Intraventricular
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Calmodulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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