| Calmodulin immunolocalization in outer segments of Xenopus laevis photoreceptors. | |
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MedLine Citation:
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PMID: 12107437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because adaptation of vertebrate photoreceptors to light is mediated by changes in the level of calcium in their outer segments (OS), proteins that bind calcium are important in phototransduction. This study has used immunofluorescence to investigate the distribution of the calcium-binding protein calmodulin within photoreceptor OS dissociated from amphibian ( Xenopus laevis) retinas. The OS of rods and cones had a streak of fluorescence to calmodulin at the ciliary axoneme. The OS of rods (but not cones) also displayed regularly spaced puncta of anti-calmodulin fluorescence along longitudinal lines coinciding with their multiple incisures. This location of calmodulin immunofluorescence closely matches the known location of microtubules within the OS of amphibian rods and cones. These findings provide evidence that calmodulin is closely associated with the microtubules of both the axonemal and incisural cytoskeletal systems in OS, and suggest that this association is important for calmodulin function in photoreceptors. |
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Authors:
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Marion S Eckmiller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2002-05-18 |
Journal Detail:
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Title: Cell and tissue research Volume: 308 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-10 Completed Date: 2003-01-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 439-42 Citation Subset: IM |
Affiliation:
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C. and O. Vogt Brain Research Institute, University Clinic, Heinrich Heine University of Düsseldorf, Postfach 101007, 40001 Düsseldorf, Germany. eckmill@hirn.uni-duesseldorf.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calmodulin / analysis* Fluorescent Antibody Technique Retinal Cone Photoreceptor Cells / chemistry* Retinal Rod Photoreceptor Cells / chemistry* Xenopus laevis |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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