Document Detail

Calmodulin and cell cycle control.
MedLine Citation:
PMID:  1343599     Owner:  NLM     Status:  MEDLINE    
Previous studies have indicated a role for the calcium receptor calmodulin in the control of eukaryotic cell proliferation. Using a molecular genetic approach in the filamentous fungus Aspergillus nidulans we have shown that CaM is required for cell cycle progression at multiple points in the cell cycle. Construction of an A nidulans strain conditional for calmodulin expression reveals that this protein is required during G1/S and for the initiation of mitosis. A lack of calmodulin results in cell cycle arrest, and a failure in polar growth that accompanies germination of A nidulans spores. In addition, increased expression of calmodulin in this organism permits growth at suboptimal calcium concentrations, indicating that cell growth is coordinately regulated by calcium and calmodulin. Together these results indicate that calmodulin-dependent processes may be conserved between A nidulans and vertebrate cells, and suggest that this approach may allow us to elucidate the molecular mechanism underlying calmodulin-regulated control of cell proliferation.
C D Rasmussen; K P Lu; R L Means; A R Means
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology, Paris     Volume:  86     ISSN:  0928-4257     ISO Abbreviation:  J. Physiol. Paris     Publication Date:  1992  
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9309351     Medline TA:  J Physiol Paris     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Canada.
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MeSH Terms
Aspergillus nidulans / cytology,  metabolism
Calmodulin / genetics,  physiology*
Cell Cycle / physiology*
Molecular Biology / methods
Reg. No./Substance:

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