Document Detail

Calls on reproductive and developmental toxicants to a regional poison center.
MedLine Citation:
PMID:  9949487     Owner:  NLM     Status:  MEDLINE    
We sought to characterize calls received by a regional Poison Center concerning reproductive hazards and to assess the quality of the responses. Data was extracted for a 3 mo period from all calls regarding reproductive or in utero developmental effects. The Poison Center responses were evaluated based on completeness of information gathered and final recommendations made. Two hundred seventy-one calls regarding 335 products were received. Ninety-seven percent of the calls concerned exposures during a pregnancy. Fifty-nine percent of the substances of concern were drugs; 32% were other chemicals; 7% were biological agents. Eleven percent of the exposures were occupational; 22% were environmental. Thirty-four percent of the exposures had not yet occurred. Sixty-two percent were characterized as no or minimal risk. For 13% of exposures, callers were advised to avoid initiating or continuing the exposure. Callers were referred to physicians or specialty services for 11% of exposures. The majority of responses were felt to be appropriate. Problematic areas included inconsistent advice and lack of referral. Discussion of exposures in light of other risk factors for and background rates of adverse reproductive outcomes, as well as more frequent referral to a specialist with expertise in reproductive toxicology was recommended.
U Luderer; J L Burgess; J E Polifka; W O Robertson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  41     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  IM    
Department of Environmental Health, University of Washington, Seattle, USA.
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MeSH Terms
Drug Administration Routes
Embryonic and Fetal Development / drug effects
Poison Control Centers*
Reproduction / drug effects*
Retrospective Studies
Risk Factors
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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