Document Detail

Callosal function in MS patients with mild and severe callosal damage as reflected by diffusion tensor imaging.
MedLine Citation:
PMID:  18582444     Owner:  NLM     Status:  MEDLINE    
In this study, callosal function was behaviourally tested in MS patients with a redundant stimuli task. Reaction times to uni- and bilateral visual stimuli are recorded. Normal subjects respond faster to bilateral than to unilateral stimuli. This effect is called the redundancy gain effect. In patients with agenesis of the corpus callosum, the redundancy gain exceeds that predicted by probability summation, suggesting a mediating influence of the corpus callosum in healthy controls. The aim of this study is to investigate the effect of callosal damage on the redundancy gain in MS patients by investigating the probability summation model. Seventeen MS patients and as many matched healthy controls performed the redundancy gain task. In order to objectify callosal damage in our MS group, diffusion tensor imaging (DTI) derived measures such as fractional anisotropy (FA) and mean diffusivity (MD) in the corpus callosum were obtained. Callosal FA and MD significantly differed in our MS group compared to the healthy controls, indicating pathological callosal involvement. Since the amount of callosal damage was highly variable within the MS group, the MS cohort was split into a low and a high callosal-injured group as quantified by FA. The high FA group performed like the healthy controls, whereas violations of the probability (race) model were found for the low FA group. We conclude that behavioural measures obtained by the redundancy gain paradigm reflect callosal pathology in MS as measured by DTI.
Nele P Warlop; Els Fieremans; Eric Achten; Jan Debruyne; Guy Vingerhoets
Related Documents :
19523044 - Fosb proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoho...
23365104 - Neuronal activity correlated with checking behaviour in the subthalamic nucleus of pati...
24863584 - Simultaneous recording of mouse retinal ganglion cells during epiretinal or subretinal ...
11268414 - The role of pro- and antiinflammatory cytokines in neurodegeneration.
12562524 - Regulation of alpha-synuclein by bfgf in cultured ventral midbrain dopaminergic neurons.
14659824 - The simultaneous in vivo perilymphatic perfusion of avian auditory and vestibular end o...
Publication Detail:
Type:  Journal Article     Date:  2008-06-11
Journal Detail:
Title:  Brain research     Volume:  1226     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-15     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  218-25     Citation Subset:  IM    
Laboratory for Neuropsychology, Department of Neurology, Ghent University, De Pintelaan 185-4K3, B-9000 Ghent, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Case-Control Studies
Corpus Callosum / pathology*,  physiopathology*
Diffusion Magnetic Resonance Imaging*
Functional Laterality
Image Processing, Computer-Assisted
Middle Aged
Multiple Sclerosis / pathology*
Neuropsychological Tests
Photic Stimulation
Reaction Time

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Controlled pulse delivery of electrical stimulation differentially reduces epileptiform activity in ...
Next Document:  Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precu...