Document Detail


Calix[4]tubes: a new class of potassium-selective ionophore.
MedLine Citation:
PMID:  11841304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new class of cryptand-like ionophore based on a bis calix[4]arene structure has been developed. These molecules proved highly selective for complexation of potassium over all group I metal cations and barium. A range of symmetric and asymmetric calix[4]tubes featuring either alkyl or phenyl substituents at the upper rim have been synthesized in exceptional yield. Alteration of the calix[4]arene upper rim environment enables fine-tuning of the rate of potassium uptake, which can be evaluated through the conformational change on binding by NMR studies. Selectivity of potassium complexation has been demonstrated using NMR and electrospray mass spectral techniques. Molecular modeling studies, derived from crystallographic data, confirm that the potassium metal cation is complexed via the axial route, passing through the calix[4]arene annulus, and provide evidence for complexation rate and selectivity.
Authors:
Susan E Matthews; Phillipe Schmitt; Vitor Felix; Michael G B Drew; Paul D Beer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  124     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-13     Completed Date:  2002-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1341-53     Citation Subset:  IM    
Affiliation:
Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QR, UK.
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MeSH Terms
Descriptor/Qualifier:
Calixarenes*
Crystallography, X-Ray
Ionophores / chemical synthesis,  chemistry*
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Molecular Structure
Phenols / chemical synthesis,  chemistry*
Potassium / chemistry*
Chemical
Reg. No./Substance:
0/Ionophores; 0/Phenols; 0/calix(4)arene; 130036-26-9/Calixarenes; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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