Document Detail

Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.
MedLine Citation:
PMID:  2717946     Owner:  NLM     Status:  MEDLINE    
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.
N Zein; M Poncin; R Nilakantan; G A Ellestad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  244     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  697-9     Citation Subset:  IM    
Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, NY 10965.
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MeSH Terms
Anti-Bacterial Agents / metabolism*
Antibiotics, Antineoplastic
Base Sequence
Binding Sites
Computer Simulation
DNA / metabolism*
Models, Molecular
Molecular Structure
Nucleic Acid Conformation
Structure-Activity Relationship
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Antibiotics, Antineoplastic; 0/Benzoates; 0/Carbohydrates; 0/Enediynes; 108212-75-5/calicheamicin gamma(1)I; 9007-49-2/DNA
Erratum In:
Science 1989 Jun 9;244(4909):following 1128

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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