Document Detail

Calf muscle hemoglobin oxygen saturation characteristics and exercise performance in patients with intermittent claudication.
MedLine Citation:
PMID:  18572363     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was conducted to determine the association between the characteristics of calf muscle hemoglobin oxygen saturation (StO(2)) and exercise performance in patients with intermittent claudication.
METHODS: The study comprised 39 patients with peripheral arterial disease limited by intermittent claudication. Patients were characterized on calf muscle StO(2) before, during, and after a graded treadmill test, as well as on demographic and cardiovascular risk factors, ankle-brachial index (ABI), ischemic window, initial claudication distance (ICD), and absolute claudication distance (ACD).
RESULTS: Calf muscle StO(2) decreased 72%, from 55% +/- 18% (mean +/- SD) saturation at rest to the minimum value of 17% +/- 19% saturation attained 459 +/- 380 seconds after the initiation of exercise. After exercise, recovery half-time of calf muscle StO(2) was attained at 129 +/- 98 seconds, whereas full recovery to the resting value was reached at 225 +/- 140 seconds. After adjusting for sex, race, and grouping according to the initial decline constant in calf muscle StO(2) during exercise, the exercise time to minimum calf muscle StO(2) was correlated with the ischemic window (r = -0.493, P = .002), ICD (r = 0.339, P = .043), and ACD (r = 0.680, P < .001). After treadmill exercise, the recovery half-time of calf muscle StO(2) was correlated with the ischemic window (r = 0.531, P < .001), ICD (r = -0.598, P < .001), and ACD (r = -0.491, P = .003).
CONCLUSION: In patients limited by intermittent claudication, shorter ICD and ACD values are associated with reaching a minimum value in calf muscle StO(2) sooner during treadmill exercise and with having a delayed recovery in calf muscle StO(2) after exercise.
Andrew W Gardner; Donald E Parker; Nykita Webb; Polly S Montgomery; Kristy J Scott; Steve M Blevins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-06-24
Journal Detail:
Title:  Journal of vascular surgery     Volume:  48     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-09-12     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  644-9     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Exercise Test
Exercise Tolerance*
Intermittent Claudication / etiology,  metabolism,  physiopathology*
Ischemia / etiology,  metabolism,  physiopathology*
Leg / blood supply*
Middle Aged
Muscle Contraction*
Muscle, Skeletal / metabolism,  physiopathology*
Oxyhemoglobins / metabolism*
Peripheral Vascular Diseases / complications,  metabolism,  physiopathology*
Recovery of Function
Time Factors
Grant Support
M01-RR-14467/RR/NCRR NIH HHS; R01 AG024296/AG/NIA NIH HHS; R01 AG024296-01A2/AG/NIA NIH HHS; R01-AG-24296/AG/NIA NIH HHS
Reg. No./Substance:

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