Document Detail

Calculation of shear stiffness in noise dominated magnetic resonance elastography data based on principal frequency estimation.
MedLine Citation:
PMID:  21701049     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance elastography (MRE) is a non-invasive phase-contrast-based method for quantifying the shear stiffness of biological tissues. Synchronous application of a shear wave source and motion encoding gradient waveforms within the MRE pulse sequence enable visualization of the propagating shear wave throughout the medium under investigation. Encoded shear wave-induced displacements are then processed to calculate the local shear stiffness of each voxel. An important consideration in local shear stiffness estimates is that the algorithms employed typically calculate shear stiffness using relatively high signal-to-noise ratio (SNR) MRE images and have difficulties at an extremely low SNR. A new method of estimating shear stiffness based on the principal spatial frequency of the shear wave displacement map is presented. Finite element simulations were performed to assess the relative insensitivity of this approach to decreases in SNR. Additionally, ex vivo experiments were conducted on normal rat lungs to assess the robustness of this approach in low SNR biological tissue. Simulation and experimental results indicate that calculation of shear stiffness by the principal frequency method is less sensitive to extremely low SNR than previously reported MRE inversion methods but at the expense of loss of spatial information within the region of interest from which the principal frequency estimate is derived.
K P McGee; D Lake; Y Mariappan; R D Hubmayr; A Manduca; K Ansell; R L Ehman
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Publication Detail:
Type:  Journal Article     Date:  2011-06-23
Journal Detail:
Title:  Physics in medicine and biology     Volume:  56     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-10-21     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  4291-309     Citation Subset:  IM    
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MeSH Terms
Biomechanical Phenomena
Elasticity Imaging Techniques / methods*
Finite Element Analysis
Lung / physiopathology,  ultrasonography
Rats, Sprague-Dawley
Shear Strength*
Grant Support
R01 EB001981/EB/NIBIB NIH HHS; R01 EB001981-13/EB/NIBIB NIH HHS; R01 EB007593/EB/NIBIB NIH HHS; R01 EB007593-01A2/EB/NIBIB NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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