Document Detail

Calculation of the Outcomes of Remodeling of Arteries Subjected to Sustained Hypertension Using a 3D Two-Layered Model.
MedLine Citation:
PMID:  23296999     Owner:  NLM     Status:  Publisher    
Arteries manifest a remodeling response to long-term alterations in arterial pressure and blood flow by changing geometry, structure, and composition through processes driven by perturbations of the local stresses in the vascular wall from their baseline values. The objective of this study is twofold-to develop a general method for calculating the remodeling responses of an artery considered as a two-layered tube; and to provide results for adaptive and maladaptive remodeling of a coronary artery. By formulating an inverse problem of vascular mechanics, the geometrical dimensions and mechanical properties of an artery are calculated from a prescribed deformed configuration, stress field, structural stiffness, and applied load. As an illustrative example we consider a human LAD coronary artery in both a perfect and incomplete adaptive response to a sustained step-wise change in pressure and a maladaptive response due to impaired remodeling of adventitia. The results obtained show that adventitia plays an important role in vascular mechanics when an artery is subjected to high arterial pressure. In addition to its well-known short term function of preventing over-inflation of an artery, it seems reasonable to accept that the manner by which adventitia remodels in response to a chronic increase in pressure is essential for preserving normal arterial function or may lead to an increased risk of developing vascular disorders.
Alexander Rachev; W Robert Taylor; Raymond P Vito
Related Documents :
10494649 - Surgical management of short bowel syndrome by construction of an isoperistaltic intest...
15922759 - Functional analysis of bioprosthetic heart valves.
19868569 - Remote results of operations on the pulmonary orifice of the heart.
7877289 - Perceptual rankings of speech quality produced with one-way tracheostomy speaking valves.
24323669 - Preparation of an autologous heart valve with a stent (stent-biovalve) using the stent ...
23608369 - Measurement of carotid stenosis using duplex ultrasonography with a microconvex array t...
17683959 - Spinal cord ischemia after endovascular repair of the descending thoracic aorta in a sh...
22495769 - Carotid mprage signal is associated with acute territorial cerebral ischemic events det...
10761799 - Aortic valve replacement for patients with mild to moderate aortic stenosis undergoing ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  -     ISSN:  1521-6047     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
College of Engineering and Computing, University of South Carolina, 300 Main, Columbia, SC, USA,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokin...
Next Document:  Characterization of biaxial mechanical behavior of porcine aorta under gradual elastin degradation.