| Calculated effect of fluid retention upon velocity of blood flow and turbulence: implications for atherosclerosis. | |
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MedLine Citation:
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PMID: 21339628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fluid retention increases intravascular volume and pressure. The calculations in this paper demonstrate that fluid retention increases the likelihood that blood will flow in a turbulent manner, in part due to an increase in stroke volume, regardless of whether or not blood pressure is increased. Increased turbulence will promote endothelial dysfunction, thereby contributing to the development of atherosclerotic cardiovascular disease. Accordingly, fluid retention is predictably detrimental to the cardiovascular system. The reason that some medications, such as cyclo-oxygenase-2 inhibitors, nonselective nonsteroidal anti-inflammatory drugs, estrogens, progestins, and rosiglitazone, are associated with an increased risk of myocardial infarcts and strokes may be that they cause fluid retention. Increased stroke volume and/or edema formation may indicate that a medication increases the risk of adverse cardiovascular events. For drugs that increase the risk of adverse cardiovascular events, it may be possible to reduce or neutralize the increased risk by simultaneously administering a diuretic. |
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Authors:
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Robert P Blankfield |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 47 ISSN: 1875-8622 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-22 Completed Date: 2011-06-01 Revised Date: 2011-10-07 |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 79-86 Citation Subset: IM |
Affiliation:
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Department of Family Medicine, Case Western Reserve University School of Medicine, Berea, OH, USA. blankfield@roadrunner.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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adverse effects Atherosclerosis / physiopathology* Blood Flow Velocity* Cyclooxygenase 2 Inhibitors / adverse effects Humans Models, Cardiovascular Myocardial Infarction / chemically induced Stroke / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase 2 Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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