Document Detail

Calcium supplementation reduces the risk of pregnancy-induced hypertension in an Andes population.
MedLine Citation:
PMID:  2679864     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested that increased dietary calcium is associated with a decreased occurrence of pregnancy-induced hypertension. In this study 106 young healthy nulliparous women, residing in Quito, Ecuador, were enrolled in a double-blind, randomized, controlled clinical trial. From 24 weeks gestation until delivery they received either 2 g of elemental calcium per day or a placebo. Calcium supplementation was associated with a significantly decreased risk of pregnancy-induced hypertension, with 4.1% developing pregnancy-induced hypertension in the treatment group versus 27.9% in the placebo group. Treatment was associated with a decrease in both systolic and diastolic blood pressure over the course of pregnancy. In addition, there was a small but significant increase in serum ionized calcium levels in the calcium-supplemented group during the treatment period.
P López-Jaramillo; M Narváez; R M Weigel; R Yépez
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  96     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-11-28     Completed Date:  1989-11-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  648-55     Citation Subset:  AIM; IM    
Laboratorio de Investigaciones en Metabolismo y Nutricion, Facultad de Ciencias Medicas, Universidad Central, Quito, Ecuador.
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MeSH Terms
Calcium / blood
Calcium Gluconate / therapeutic use*
Double-Blind Method
Gluconates / therapeutic use*
Hypertension / prevention & control*
Pregnancy Complications, Cardiovascular / prevention & control*
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Gluconates; 299-28-5/Calcium Gluconate; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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