| Calcium oxalate stone and gout. | |
| | |
MedLine Citation:
|
PMID: 19779706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Gout is well known to be produced by increased uric acid level in blood. The objective of this paper is to assess the relationship between gout and calcium oxalate stone formation in the humans. 48 patients with combination of gout and calcium oxalate stone problem were included. The biochemical values of this group were compared with 38 randomly selected uric acid stone patients with gout, 43 stone patients with gout alone, 100 calcium oxalate stone patients without gout and 30 controls, making a total of 259 patients. Various biochemical parameters, namely serum calcium, phosphorus and uric acid and 24-h urine calcium, phosphorus, uric acid, oxalate, citrate and magnesium were analysed. ANOVA and Duncan's multiple-range tests were performed to assess statistical significance of the variations. The promoters of stone formation, namely serum calcium (P < 0.05), phosphorus (P < 0.05) and uric acid (P < 0.05) and urine calcium (P < 0.05), uric acid (P < 0.05) and oxalate (P < 0.05) were significantly variable in the different groups. The inhibitor citrate (P < 0.05) was also significantly variable. Multiple-range test showed that the promoters, namely serum calcium (P < 0.05) and urine uric acid (P < 0.05) were in a significantly higher range in the gouty patients, gouty uric acid stone patients and gouty calcium oxalate stone patients compared to the non-gouty patients and controls. Urine oxalate (P < 0.0001) was in the highest range in the gouty calcium oxalate or gouty uric acid stones patients. The inhibitor urine citrate (P < 0.001) was significantly lower in the gouty, gouty uric acid and gouty calcium oxalate patients. Serum uric acid was highest in the non-stone gouty patients, followed by the gouty uric acid stone formers and gouty calcium oxalate stone patients. The high values of promoters, namely uric acid and calcium in the gouty stone patients indicate the tendency for urinary stone formation in the gouty stone patients. There is probably a correlation between gout and calcium oxalate urinary stone. We presume this mechanism is achieved through the uric acid metabolism. The findings point to the summation effect of metabolic changes in development of stone disease. |
| | |
Authors:
|
Y M Fazil Marickar |
Related Documents
:
|
16967186 - Electrocatalytic reduction of hydrogen peroxide on modified graphite electrodes: applic... 18048076 - Comparative study of ozonation and synthetic goethite-catalyzed ozonation of individual... 15453686 - Chemical composition and protein quality comparisons of soybeans and soybean meals from... 1756626 - Effect of tarnish on copper release. 18027966 - Chemistry of 4-alkylaryloxenium ion "precursors": sound and fury signifying something? 7660736 - Polarization microscopic investigation of collagen and acid glycosaminoglycans in the s... |
Publication Detail:
|
Type: Journal Article Date: 2009-09-25 |
Journal Detail:
|
Title: Urological research Volume: 37 ISSN: 1434-0879 ISO Abbreviation: Urol. Res. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-01-29 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0364311 Medline TA: Urol Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 345-7 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Zensa Hospital, Trivandrum, 695009, India. fazilmarickar@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Calcium
/
metabolism Calcium Oxalate / metabolism* Case-Control Studies Gout / metabolism* Humans Phosphorus / metabolism Uric Acid / metabolism Urinary Calculi / metabolism* |
| Chemical | |
Reg. No./Substance:
|
25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid; 7440-70-2/Calcium; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating tr...
Next Document: Cystinuria: the South Indian experience.