Document Detail


Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B₁ exposure in rats and humans.
MedLine Citation:
PMID:  22324939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fumonisin B₁ (FB₁) is often a co-contaminant with aflatoxin (AF) in grains and may enhance AF's carcinogenicity by acting as a cancer promoter. Calcium montmorillonite (i.e. NovaSil, NS) is a possible dietary intervention to help decrease chronic aflatoxin exposure where populations are at risk. Previous studies show that an oral dose of NS clay was able to reduce AF exposure in a Ghanaian population. In vitro analyses from our laboratory indicated that FB₁ (like aflatoxin) could also be sorbed onto the surfaces of NS. Hence, our objectives were to evaluate the efficacy of NS clay to reduce urinary FB₁ in a rodent model and then in a human population highly exposed to AF. In the rodent model, male Fisher rats were randomly assigned to either FB₁ control, FB₁ + 2% NS or absolute control group. FB₁ alone or with clay was given as a single dose by gavage. For the human trial, participants received NS (1.5 or 3 g day⁻¹) or placebo (1.5 g day⁻¹) for 3 months. Urines from weeks 8 and 10 were collected from the study participants for analysis. In rats, NS significantly reduced urinary FB₁ biomarker by 20% in 24 h and 50% after 48 h compared to controls. In the humans, 56% of the urine samples analysed (n = 186) had detectable levels of FB₁. Median urinary FB₁ levels were significantly (p < 0.05) decreased by >90% in the high dose NS group (3 g day⁻¹) compared to the placebo. This work indicates that our study participants in Ghana were exposed to FB₁ (in addition to AFs) from the diet. Moreover, earlier studies have shown conclusively that NS reduces the bioavailability of AF and the findings from this study suggest that NS clay also reduces the bioavailability FB₁. This is important since AF is a proven dietary risk factor for hepatocellular carcinoma (HCC) in humans and FB₁ is suspected to be a dietary risk factor for HCC and oesophageal cancer in humans.
Authors:
A Robinson; N M Johnson; A Strey; J F Taylor; A Marroquin-Cardona; N J Mitchell; E Afriyie-Gyawu; N A Ankrah; J H Williams; J S Wang; P E Jolly; R J Nachman; T D Phillips
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Publication Detail:
Type:  Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-02-10
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  29     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-08-21     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  809-18     Citation Subset:  IM    
Affiliation:
College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4458, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Aflatoxins / administration & dosage,  toxicity
Animals
Antidotes / administration & dosage,  therapeutic use*
Bentonite / administration & dosage,  therapeutic use*
Biological Markers / blood,  urine
Carcinogens, Environmental / administration & dosage,  analysis*,  chemistry*,  pharmacokinetics
Diet / adverse effects
Dose-Response Relationship, Drug
Double-Blind Method
Female
Fumonisins / administration & dosage,  analysis*,  antagonists & inhibitors*,  pharmacokinetics
Ghana
Humans
Male
Middle Aged
Random Allocation
Rats
Rats, Inbred F344
Young Adult
Grant Support
ID/Acronym/Agency:
1R01MD005819-01/MD/NIMHD NIH HHS; R01 MD005819/MD/NIMHD NIH HHS; R01 MD005819-01/MD/NIMHD NIH HHS
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Antidotes; 0/Biological Markers; 0/Carcinogens, Environmental; 0/Fumonisins; 116355-83-0/fumonisin B1; 1302-78-9/Bentonite
Comments/Corrections

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