| Calcium microdomains and cell cycle control. | |
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MedLine Citation:
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PMID: 17045645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell division cycle comprises successive rounds of genome replication and segregation that are never error-free. A complex signalling network chaperones cell cycle events to ensure that cell cycle progression does not occur until any errors detected are put right. The signalling network consists of cell cycle control proteins that are phosphorylated and dephosphorylated, synthesized and degraded interactively to generate a set of sensors and molecular switches that are thrown at appropriate times to permit or trigger cell cycle progression. In early embryos, discrete calcium signals have been shown to be a key component of the molecular switch mechanism. In somatic cells in contrast, the participation of calcium signals in cell cycle control is far from clear. Recent experiments in syncytial Drosophila embryos have shown that localised calcium signals in the nucleus and mitotic spindle can be detected. It appears that the nucleus comprises a calcium signalling microdomain bounded by endoplasmic reticulum that isolates the nucleus and spindle. These findings offer a possible explanation for the apparent absence of calcium signals in somatic cells during mitosis. |
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Authors:
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Michael Whitaker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-10-12 |
Journal Detail:
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Title: Cell calcium Volume: 40 ISSN: 0143-4160 ISO Abbreviation: Cell Calcium Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-11-07 Completed Date: 2007-01-12 Revised Date: 2012-03-05 |
Medline Journal Info:
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Nlm Unique ID: 8006226 Medline TA: Cell Calcium Country: Scotland |
Other Details:
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Languages: eng Pagination: 585-92 Citation Subset: IM |
Affiliation:
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Institute of Cell and Molecular Biosciences, Medical School, Framlington Place, Newcastle upon Tyne, UK. michael.whitaker@ncl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Signaling / physiology* Cell Cycle / physiology* Cell Nucleus / physiology Drosophila / embryology Embryo, Nonmammalian / physiology Endoplasmic Reticulum / physiology, ultrastructure Membrane Microdomains / physiology* Mitotic Spindle Apparatus / physiology |
| Grant Support | |
ID/Acronym/Agency:
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080374//Wellcome Trust; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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