Document Detail


Calcium metabolism in hypertension.
MedLine Citation:
PMID:  8587222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High blood pressure, one of the most common chronic diseases in industrialized societies, is a primary risk factor for cardiovascular disease, heart failure, renal disease and stroke. Data from both epidemiologic surveys and clinical trials have shown that calcium metabolism is altered in persons with hypertension, indicating a primary role of calcium in the etiology, prevention, and treatment of hypertension. Investigative efforts throughout the world have identified abnormalities in a number of biochemical parameters of calcium metabolism and a consistently low intake of dietary calcium in persons with high blood pressure. Calcium supplementation trials have reported varying results in terms blood pressure response, and it is generally concluded that many hypertensive patients may benefit from increased calcium intake. The blood pressure-lowering effect of calcium may be of particular benefit to the elderly, people of African origin, and pregnant women. Interactions between dietary nutrients have been shown to be critical in the effect of calcium on blood pressure, particularly sodium and potassium. Finally, based on the body of data that has accumulated in this area, calcium intake is postulated to have clinical application in the treatment of sodium-sensitive, alcohol-associated, and pregnancy-induced hypertension, and type II diabetes mellitus; and adequate, long-term calcium intake may be a means of preventing the development of hypertension.
Authors:
D A McCarron
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Keio journal of medicine     Volume:  44     ISSN:  0022-9717     ISO Abbreviation:  Keio J Med     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-03-27     Completed Date:  1996-03-27     Revised Date:  2008-08-07    
Medline Journal Info:
Nlm Unique ID:  0376354     Medline TA:  Keio J Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  105-14     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Aged
Alcoholism / complications
Blood Pressure / drug effects
Calcium / metabolism*
Calcium, Dietary / administration & dosage
Diabetes Mellitus, Type 2 / complications
Epidemiologic Factors
Female
Humans
Hypertension / diet therapy,  etiology,  metabolism*
Male
Pregnancy
Pregnancy Complications, Cardiovascular / metabolism
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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