Document Detail

Calcium metabolism and familial risk of hypertension.
MedLine Citation:
PMID:  8588111     Owner:  NLM     Status:  MEDLINE    
There is circumstantial evidence that disturbances of calcium metabolism are implicated in primary hypertension. From a large number of observational epidemiological studies, data have shown that a low dietary calcium intake increases the risk for high blood pressure. There is no general sensitivity for the effects of inadequate calcium intake, but subgroups of hypertensive patients have been described characterized by reduced serum ionized calcium levels, increased urinary excretion of calcium, raised intracellular calcium levels, reduced cellular membrane calcium binding, and other indicators of a relative calcium need. Some of these changes, however, may be secondary to blood pressure elevation. The family history approach enables to study the pathophysiology of early primary hypertension, at a stage at which blood pressure differences between future hypertensive subjects and normotensive subjects are still limited. In the Dutch Hypertension and Offspring Study, young normotensive subjects were studied selected on the basis of presence or absence of familial predisposition for hypertension. The findings show that disturbances in calcium metabolism are present in the early phase of primary hypertension and may precede the development of high blood pressure. Moreover, they suggest that changes in calcium metabolism may be a characteristic of familial hypertension and could reflect a genetic basis for calcium sensitive hypertension. The presence of a relatively reduced serum calcium and increased plasma PTH [1-84] level in the offspring of hypertensive parents indicates that calcium balance in prehypertensive subjects is maintained at a higher level of circulating PTH. The implications of these findings in relation to other available data are discussed.
D E Grobbee; I M van Hooft; A Hofman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  15     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-03-28     Completed Date:  1996-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-8     Citation Subset:  IM    
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
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MeSH Terms
Calcium / metabolism*
Hypertension / epidemiology,  genetics*,  metabolism*
Middle Aged
Netherlands / epidemiology
Risk Factors
Reg. No./Substance:

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