| Calcium ketovaline as new therapy for uremic hyperphosphatemia. | |
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MedLine Citation:
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PMID: 2089249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since treatment of uremic hyperphosphatemia still represents a major problem and phosphate-binding agents carry the well-known risk of aluminum intoxication, we carried out a study to determine whether calcium ketovaline, a keto acid containing calcium, would show phosphate-binding effects comparable to those obtained with a mixture of amino acids and calcium salts of ketoanalogues tested previously. In vitro as well as in vivo studies show convincingly that calcium ketovaline is a valuable intestinal phosphate binder. Dialysis patients treated for 6 weeks showed a significant (p less than 0.05) decrease in serum phosphate from 2.36 +/- 0.19 to 1.81 +/- 0.16 mmol/l. |
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Authors:
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K Schaefer; D von Herrath; C M Erley; G Asmus |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Mineral and electrolyte metabolism Volume: 16 ISSN: 0378-0392 ISO Abbreviation: Miner Electrolyte Metab Publication Date: 1990 |
Date Detail:
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Created Date: 1991-05-28 Completed Date: 1991-05-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802196 Medline TA: Miner Electrolyte Metab Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 362-4 Citation Subset: IM |
Affiliation:
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Medizinische Abteilung II, St. Joseph-Krankenhaus I, Berlin. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Keto Acids / therapeutic use* Phosphates / blood* Renal Dialysis Uremia / complications, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Keto Acids; 0/Phosphates; 759-05-7/alpha-ketoisovalerate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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