Document Detail

Calcium ketovaline as new therapy for uremic hyperphosphatemia.
MedLine Citation:
PMID:  2089249     Owner:  NLM     Status:  MEDLINE    
Since treatment of uremic hyperphosphatemia still represents a major problem and phosphate-binding agents carry the well-known risk of aluminum intoxication, we carried out a study to determine whether calcium ketovaline, a keto acid containing calcium, would show phosphate-binding effects comparable to those obtained with a mixture of amino acids and calcium salts of ketoanalogues tested previously. In vitro as well as in vivo studies show convincingly that calcium ketovaline is a valuable intestinal phosphate binder. Dialysis patients treated for 6 weeks showed a significant (p less than 0.05) decrease in serum phosphate from 2.36 +/- 0.19 to 1.81 +/- 0.16 mmol/l.
K Schaefer; D von Herrath; C M Erley; G Asmus
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Mineral and electrolyte metabolism     Volume:  16     ISSN:  0378-0392     ISO Abbreviation:  Miner Electrolyte Metab     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-28     Completed Date:  1991-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802196     Medline TA:  Miner Electrolyte Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  362-4     Citation Subset:  IM    
Medizinische Abteilung II, St. Joseph-Krankenhaus I, Berlin.
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MeSH Terms
Keto Acids / therapeutic use*
Phosphates / blood*
Renal Dialysis
Uremia / complications,  drug therapy*
Reg. No./Substance:
0/Keto Acids; 0/Phosphates; 759-05-7/alpha-ketoisovalerate

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