Document Detail

Calcium, iron, and zinc uptake from digests of infant formulas by Caco-2 cells.
MedLine Citation:
PMID:  11453795     Owner:  NLM     Status:  MEDLINE    
Our aim was to estimate the bioavailability of calcium, iron, and zinc from infant formulas using a model that includes in vitro digestion and a Caco-2 cell culture to estimate the uptake. The cell culture conditions were selected, and uptake assays were carried out first with calcium, iron, and zinc standard solutions, and then with the soluble fraction of enzymatic digests of an adapted milk-based and a soy-based infant formula. It was not possible to measure the uptake of calcium, iron, and zinc from standard solutions added to the cell cultures in amounts similar to those present in infant formula digests with our method. The fact that it was, however, possible in the case of enzymatic digests suggests the presence of components in the digests that enhance mineral uptake. When mineral uptakes were expressed as percentages of the mineral present, statistically significant differences were found in the case of calcium between the uptake from the milk- and the soy-based formulas. For iron and zinc no such differences were observed.
M Jovaní; R Barberá; R Farré; E Martín de Aguilera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  49     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3480-5     Citation Subset:  IM    
Nutrition and Food Chemistry, Faculty of Pharmacy, University of Valencia, Avda Vicente Andrés Estellés, s/n. 46100, Burjassot Valencia, Spain.
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MeSH Terms
Biological Availability
Caco-2 Cells
Calcium, Dietary / pharmacokinetics*
Infant Food / analysis*
Infant, Newborn
Intestinal Absorption
Iron, Dietary / pharmacokinetics*
Models, Biological
Zinc / pharmacokinetics*
Reg. No./Substance:
0/Calcium, Dietary; 0/Iron, Dietary; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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