Document Detail


Calcium ion sequestration by N-acylamino acids within the rectal membrane and the enhancement of the rectal absorption of sodium ampicillin in rats.
MedLine Citation:
PMID:  2760826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study reports the contribution of the calcium ion sequestration capacity of N-acylamino acids, used as absorption promoters, to their absorption-promoting action. Different extents of enhanced rectal absorption of sodium ampicillin by N-acylamino acids were well explained by the predicted amount of calcium ion sequestrated by N-acylamino acids existing in the rectal membranes. The amount of N-acylamino acids that penetrated into the rectal membrane was predicted by the product of the Rm value and the dose of N-acylamino acids. Thus, in the present study, it was demonstrated that the extent of the promoting effect of adjuvants at various doses on the membrane permeability may be predicted by multiplying the calcium ion sequestration capacity obtained in vitro by the lipophilicity and the dose applied to the rectal lumen of adjuvants.
Authors:
W M Wu; T Murakami; R Yamajo; Y Higashi; N Yata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  78     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-21     Completed Date:  1989-09-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-503     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Ampicillin / administration & dosage,  pharmacokinetics*
Animals
Calcium / pharmacokinetics*
Chemistry, Physical
Chromatography, Gas
Intestinal Absorption
Male
Membranes / metabolism
Physicochemical Phenomena
Rats
Rats, Inbred Strains
Rectum / metabolism*
Surface Tension
Chemical
Reg. No./Substance:
0/Amino Acids; 69-53-4/Ampicillin; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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