| Calcium ion sequestration by N-acylamino acids within the rectal membrane and the enhancement of the rectal absorption of sodium ampicillin in rats. | |
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MedLine Citation:
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PMID: 2760826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study reports the contribution of the calcium ion sequestration capacity of N-acylamino acids, used as absorption promoters, to their absorption-promoting action. Different extents of enhanced rectal absorption of sodium ampicillin by N-acylamino acids were well explained by the predicted amount of calcium ion sequestrated by N-acylamino acids existing in the rectal membranes. The amount of N-acylamino acids that penetrated into the rectal membrane was predicted by the product of the Rm value and the dose of N-acylamino acids. Thus, in the present study, it was demonstrated that the extent of the promoting effect of adjuvants at various doses on the membrane permeability may be predicted by multiplying the calcium ion sequestration capacity obtained in vitro by the lipophilicity and the dose applied to the rectal lumen of adjuvants. |
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Authors:
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W M Wu; T Murakami; R Yamajo; Y Higashi; N Yata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 78 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-09-21 Completed Date: 1989-09-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 499-503 Citation Subset: IM |
Affiliation:
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Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Ampicillin / administration & dosage, pharmacokinetics* Animals Calcium / pharmacokinetics* Chemistry, Physical Chromatography, Gas Intestinal Absorption Male Membranes / metabolism Physicochemical Phenomena Rats Rats, Inbred Strains Rectum / metabolism* Surface Tension |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 69-53-4/Ampicillin; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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