Document Detail

Calcium intake is not related to breast cancer risk among Singapore Chinese women.
MedLine Citation:
PMID:  23319293     Owner:  NLM     Status:  MEDLINE    
There is experimental evidence that calcium protects against breast cancer development. Prospective epidemiologic studies supporting a protective effect of calcium on breast cancer risk have mainly been limited to Western populations. We examined the association between calcium intake and breast cancer risk in the Singapore Chinese Health Study, a large population-based prospective cohort. Calcium intake and supplement use was assessed by in-person interviewer using a validated food frequency questionnaire. After a mean follow-up of 14.2±3.5 years, 823 cohort participants developed invasive breast cancer. Multivariate proportional hazards regression models were fitted to examine the associations between calcium intake and breast cancer risk. Vegetables were the primary food source of calcium in this study population, followed by dairy products, grains and soy foods. Calcium intake was not associated with breast cancer risk, comparing highest quartile (>345.6 mg/1,000 kcal/day) to lowest quartile (<204.5 mg/1,000 kcal/day) of intake. There was no evidence of effect modification by menopausal status, body mass index, dietary vitamin D or stage of disease at diagnosis. Our findings do not support a hypothesis for calcium in breast cancer chemoprevention, contrary to findings from previous studies among Western populations with higher calcium intake primarily from dairy products and supplements.
Jingmei Li; Woon-Puay Koh; Ai-Zhen Jin; Jian-Min Yuan; Mimi C Yu; Lesley M Butler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-03-13
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  133     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-05-22     Completed Date:  2013-07-25     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 UICC.
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MeSH Terms
Breast Neoplasms / epidemiology*,  prevention & control*
Calcium, Dietary / administration & dosage*
China / epidemiology
Dairy Products
Dietary Supplements
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Proportional Hazards Models
Risk Factors
Singapore / epidemiology
Soy Foods
Vitamin D
Grant Support
R01 CA080205/CA/NCI NIH HHS; R01 CA144034/CA/NCI NIH HHS; R01 CA144034/CA/NCI NIH HHS; R01 CA80205/CA/NCI NIH HHS
Reg. No./Substance:
0/Calcium, Dietary; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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