| Calcium homeostasis influences epidermal sweating in patients with vitiligo. | |
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MedLine Citation:
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PMID: 9274629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with vitiligo have a decreased sweating response in both their lesional and non-lesional skin (n = 17) compared with healthy age- and sex-matched controls (n = 22) after stimulation with the acetylcholine agonist pilocarpine. The decreased cholinergic response of the dermal sweat glands in this patient group correlates with a significantly lower calcium concentration in sweat compared with controls. In addition, a significantly higher potassium concentration was found in the pigmented skin of these patients. The other fast exchange ions sodium and chloride are unaffected. In vitiligo, there was a marginal sweat induction after adrenergic stimulation in four of 10 patients tested whereas all controls (n = 10) did not show any response. |
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Authors:
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S M Elwary; K Headley; K U Schallreuter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of dermatology Volume: 137 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-09-19 Completed Date: 1997-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 81-5 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, University of Bradford, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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agonists Adolescent Adult Aged Calcium / metabolism* Chlorides / metabolism Epidermis / metabolism, physiopathology* Female Homeostasis Humans Iontophoresis Male Middle Aged Muscarinic Agonists / diagnostic use Pilocarpine / diagnostic use Potassium / metabolism Sodium / metabolism Stimulation, Chemical Sweating / drug effects* Vitiligo / metabolism, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Muscarinic Agonists; 51-84-3/Acetylcholine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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