Document Detail


Calcium handling proteins: structure, function, and modulation by exercise.
MedLine Citation:
PMID:  23436107     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation-contraction process in the heart among those are sarcoplasmic reticulum Ca(2+)-ATPase, phospholamban, calsequestrin, sodium-calcium exchanger, L-type calcium's channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.
Authors:
Jamille Locatelli; Leonardo V M de Assis; Mauro C Isoldi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-24
Journal Detail:
Title:  Heart failure reviews     Volume:  -     ISSN:  1573-7322     ISO Abbreviation:  Heart Fail Rev     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612481     Medline TA:  Heart Fail Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Prêto, Brazil.
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