Document Detail


Calcium exchange and calcium-related effects in normal and sickle cell anemia erythrocytes.
MedLine Citation:
PMID:  148652     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is an exchangeable calcium pool in both normal and sickle cell erythrocytes, comprising about 10-15% of the total cellular calcium. Sickle cells show increased calcium as compared to normal cells in the oxygenated state. Specific differences between sickle and normal cells which may be associated with this fact are an increased rate of calcium exchange in sickle cells at low external calcium, an increased "leak" of calcium into sickle cells (i.e., phosphate independent exchange), and a pattern of magnesium loss in sickle cells which is consistent with a Mg-Ca exchange diffusion resulting in the increased intracellular calcium in these cells. The exchangeable calcium in sickle cells is more labile, almost all of it being available for re-exchange out of the cell over a short-time-course experiment. Analyses of flexibility and osmotic fragility of sickle cells are consistent with expected effects of increased intracellular calcium.
Authors:
B F Cameron; P Smariga
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  20     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1978  
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / metabolism
Anemia, Sickle Cell / blood*,  physiopathology
Biological Transport / drug effects
Calcium / blood*
Cations / blood
Erythrocytes / metabolism
Erythrocytes, Abnormal / metabolism*,  physiopathology
Humans
Magnesium / blood
Osmolar Concentration
Phosphates / pharmacology
Chemical
Reg. No./Substance:
0/Cations; 0/Phosphates; 7439-95-4/Magnesium; 7440-70-2/Calcium; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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